Evidence map›Paper›PMID 42432050›Full record

ArticleNature human behaviour2026

Common and rare genetic variant associations with cognitive performance across development in British birth cohorts.

Daniel S Malawsky, Mahmoud Koko, Petr Danacek, Wei Huang, Olivia Wootton, Qin Qin Huang, Emma E Wade, Sarah J Lindsay, Rosalind Arden, Matthew E Hurles and 1 more

Abstract read
In one paragraph

Article in Nature human behaviour, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Daniel S MalawskyHuman Genetics Programme, Wellcome Sanger Institute, Hinxton, UK. dm22@sanger.ac.uk.ORCID http://orcid.org/0000-0003-4421-8688
Mahmoud KokoHuman Genetics Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-9512-0184
Petr DanacekHuman Genetics Programme, Wellcome Sanger Institute, Hinxton, UK.
Wei HuangHuman Genetics Programme, Wellcome Sanger Institute, Hinxton, UK.
Olivia WoottonHuman Genetics Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-2433-4975
Qin Qin HuangHuman Genetics Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-3073-717X
Emma E WadeHuman Genetics Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-8138-6889
Sarah J LindsayHuman Genetics Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-0965-3070
Rosalind ArdenCentre for Philosophy of Natural and Social Science, London School of Economics and Political Science, London, UK.
Matthew E HurlesHuman Genetics Programme, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-2333-7015
Hilary C MartinHuman Genetics Programme, Wellcome Sanger Institute, Hinxton, UK. hcm@sanger.ac.uk.ORCID http://orcid.org/0000-0002-4454-9084

Funding

Wellcome TrustWellcome Trust (Wellcome) 220540/Z/20/A
6 · The paper itself

Abstract

Genetic variants that correlate with adult cognitive performance are also associated with rare neurodevelopmental conditions involving cognitive deficits in children. However, their association with cognition across early life remains poorly understood. Using 6,495 children from the Avon Longitudinal Study of Parents and Children, we show that, as children age, the association between cognitive ability and polygenic indices for educational attainment and its cognitive component increases (PGI

Indexed as

Child DevelopmentCognitionGenetic VariationBirth CohortChildChild, PreschoolEducational StatusFemaleGenetic Risk ScoreHumansLongitudinal StudiesMaleMultifactorial InheritancePhenotypeUnited Kingdom

Identifiers

PMID42432050
PMCPMC13590407

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.