Evidence map›Paper›PMID 42431905›Full record

ArticleTranslational psychiatry2026

Elucidating psychosocial outcome profiles as a function of aggregate genetic risk for suicide attempt and alcohol use disorder.

Alexis C Edwards, Henrik Ohlsson, Mallory Stephenson, Séverine Lannoy, Casey Crump, Jan Sundquist, Kenneth S Kendler, Kristina Sundquist

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexis C EdwardsVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, US. alexis.edwards@vcuhealth.org.ORCID http://orcid.org/0000-0002-4006-9710
Henrik OhlssonCenter for Primary Health Care Research, Lund University, Malmö, Sweden.
Mallory StephensonVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, US.ORCID http://orcid.org/0000-0002-1498-4333
Séverine LannoyVirginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, US.ORCID http://orcid.org/0000-0001-7773-4553
Casey CrumpDepartment of Family and Community Medicine, McGovern Medical School, The University of Texas Health Science Center, Houston, TX, US.ORCID http://orcid.org/0000-0002-2990-1166
Jan SundquistCenter for Primary Health Care Research, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0001-7228-5015
Kenneth S Kendler *Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, US.ORCID http://orcid.org/0000-0001-8689-6570
Kristina Sundquist *Center for Primary Health Care Research, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0001-8031-279X

Funding

The Etiology of Risk: Alcohol Use Disorder and Suicidal BehaviorR01AA027522 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI Alexis C Edwards, Kristina Sundquist · 2019 to 2026
$3.5M
NIAAA NIH HHS R01 AA027522U.S. Department of Health & Human Services | National Institutes of Health (NIH) AA027522Vetenskapsrådet (Swedish Research Council) 2021-06467Vetenskapsrådet (Swedish Research Council) 2024-02796
6 · The paper itself

Abstract

Genetic factors contribute to alcohol use disorder (AUD) and suicide attempt (SA) co-occurrence. Whether individuals with high genetic liability to one outcome versus the other, or to both, differ in terms of their risk for other psychosocial outcomes is unexplored. To this end, the authors conducted a cohort study of Swedish individuals born 1965-1985, with follow-up through December 31, 2018. Using deciles of family genetic risk scores (FGRS), a measure of aggregate genetic liability, they characterized individuals as being in a "risk" group with high/low FGRS or a "reference" with median FGRS. Within each of five comparisons, they calculated correlations between genetic profile and psychosocial outcomes. Groups included up to N = 536 312 individuals. The mean (SD) age at end of follow-up was 44.1 (6.1) years. High genetic liability to both AUD and SA was most prominently correlated with negative outcomes, e.g., r = 0.51 for drug use disorder. High FGRS

Indexed as

AlcoholismGenetic Predisposition to DiseasePsychosocial FunctioningSuicide, AttemptedAdultCohort StudiesFemaleGenetic Risk ScoreHumansMaleRisk FactorsSweden

Identifiers

PMID42431905
PMCPMC13639089

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.