ReviewCell death discovery2026
HMGA proteins in the nervous system: role in brain tumorigenesis and neurodegeneration.
Review in Cell death discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High Mobility Group A (HMGA) proteins function as non-histone chromatin-associated architectural regulators that modulate gene transcription by modifying chromatin structure rather than binding DNA in a sequence-specific manner. By altering chromatin conformation, HMGA proteins coordinate complex transcriptional programs essential in both physiological and pathological conditions. This review highlights their emerging roles in the context of the nervous system, brain tumorigenesis, and neurodegeneration. We discuss how HMGA-mediated chromatin remodeling and transcriptional regulation influence neurodevelopmental processes, regulating neural stem cell proliferation, differentiation, and lineage specification. We also highlight evidence linking HMGA dysregulation to malignant transformation and progression of brain tumors, where these proteins support oncogenic transcriptional networks. Finally, we explore their possible involvement in molecular pathways associated with neurodegenerative disorders. By integrating findings from developmental neurobiology, oncology, and neurodegeneration research, we aim to provide a comprehensive overview of HMGA proteins as pivotal regulators of neural homeostasis and highlights their potential as biomarkers and therapeutic targets in neurological diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.