Trial reportBMJ open2026
Transcatheter aortic valve implantation outcomes by patient age and sex in COMPARE-TAVI 1: a cohort study.
Trial report in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04443023 (Randomized Comparison of Eligible TAVI-valves - Cohort B), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Randomized Comparison of Eligible TAVI-valves - Cohort B (Sapien Versus Myval)
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo explore the outcomes among patients treated with TAVI (transcatheter aortic valve implantation) in the COMPARE-TAVI 1 trial by age groups and sex.
designCohort study.
settingThree Danish university hospitals.
participantsPatients treated with TAVI in the COMPARE-TAVI 1 trial (N=1030), 60 (5.8%), 337 (32.7%), 592 (57.5%) and 41 (4.0%) were in the four age groups, < 70, 70-79, 80-89 and 90+ years while 414 (40.2%) and 616 (59.8%) were of female and male sex.
interventionsTransfemoral TAVI with balloon-expandable valves (Sapien or Myval) performed between June 2020 and November 2023. OUTCOME MEASURES: Post hoc analyses of trial secondary outcomes that include end-point committee-adjudicated outcomes.
resultsIn the four age groups, 1-year mortality rates were 8.3%, 5.6%, 5.6% and 7.3% while it was 5.8% in both sexes. Across the four age groups, 1-year stroke rates were 6.7%, 1.8%, 3.2% and 4.9%, and 5.1% among females and 4.7% among males. In the four age groups, 1-year new pacemaker rates were 7.5%, 15%, 19% and 13% while it was 15% among females and 18% among males. Females had smaller annuli than males and their gradients were higher and the effective orifice area lower after TAVI but their frequency of prosthesis-patient mismatch was similar at 1 year.
conclusionWhile comorbidity levels varied between groups, clinical outcomes were similar across age groups and between sexes. TRIAL REGISTRATION NUMBER: NCT04443023.
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