Evidence map›Paper›PMID 42431644›Full record

ArticleRMD open2026

Genetic associations of eosinophilic granulomatosis with polyangiitis in the Japanese population: exploring similarities and differences with European populations.

Aya Kawasaki, Ikue Ito-Naito, Mina Sato, Yuka Kawamura, Ken-Ei Sada, Kenji Itoh, Nobuyuki Ono, Fumio Hirano, Tomoaki Higuchi, Shigeto Kobayashi and 19 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RMD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Aya KawasakiMolecular and Genetic Epidemiology Laboratory, University of Tsukuba Institute of Medicine, Tsukuba, Japan tsuchiya.naoyuki.gm@u.tsukuba.ac.jp a-kawasaki@md.tsukuba.ac.jp.ORCID http://orcid.org/0000-0002-5142-5610
Ikue Ito-NaitoMolecular and Genetic Epidemiology Laboratory, University of Tsukuba Institute of Medicine, Tsukuba, Japan.ORCID http://orcid.org/0009-0000-1707-5277
Mina SatoMolecular and Genetic Epidemiology Laboratory, University of Tsukuba Institute of Medicine, Tsukuba, Japan.
Yuka KawamuraMolecular and Genetic Epidemiology Laboratory, University of Tsukuba Institute of Medicine, Tsukuba, Japan.
Ken-Ei SadaDepartment of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Okayama, Japan.ORCID http://orcid.org/0000-0003-1020-0818
Kenji ItohDivision of Hematology and Rheumatology, National Defense Medical College, Tokorozawa, Japan.
Nobuyuki OnoDepartment of Rheumatology, Faculty of Medicine, Saga University, Saga, Japan.
Fumio HiranoDepartment of Lifetime Clinical Immunology, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Tomoaki HiguchiDivision of Rheumatology, Department of Internal Medicine, Tokyo Women's Medical University, Tokyo, Japan.ORCID http://orcid.org/0000-0002-9108-2560
Shigeto KobayashiDepartment of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan.
Kenji NagasakaDepartment of Rheumatology, Ome Medical Center, Ome, Japan.
Takahiko SugiharaDepartment of Rheumatology, Institute of Science Tokyo, Tokyo, Japan.
Takashi FujimotoDepartment of General Medicine, Nara Medical University, Nara, Japan.ORCID http://orcid.org/0000-0002-0295-7995
Makio KusaoiDepartment of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0003-0064-4765
Yuya KondoDepartment of Rheumatology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.ORCID http://orcid.org/0000-0002-1708-4402
Kumiko ShimoyamaDivision of Immunology and Rheumatology, Department of Internal Medicine 3, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Keita YamashitaMolecular and Genetic Epidemiology Laboratory, University of Tsukuba Institute of Medicine, Tsukuba, Japan.
Takashi HiguchiMolecular and Genetic Epidemiology Laboratory, University of Tsukuba Institute of Medicine, Tsukuba, Japan.
Hajime KonoDepartment of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0002-4578-8677
Noriyoshi OgawaDivision of Immunology and Rheumatology, Department of Internal Medicine 3, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Isao MatsumotoDepartment of Rheumatology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Kunihiro YamagataDepartment of Nephrology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Takayuki SumidaDepartment of Rheumatology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
Hiroshi HashimotoSchool of Medicine, Juntendo University, Tokyo, Japan.
Hirofumi MakinoOkayama University, Okayama, Japan.
Yoshihiro ArimuraDepartment of Nephrology and Rheumatology, Kyorin University, Tokyo, Japan.
Masayoshi HarigaiDepartment of Rheumatology, International University of Health and Welfare School of Medicine, Chiba, Japan.ORCID http://orcid.org/0000-0002-6418-2603
Naoto TamuraDepartment of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0003-1729-2954
Naoyuki TsuchiyaMolecular and Genetic Epidemiology Laboratory, University of Tsukuba Institute of Medicine, Tsukuba, Japan tsuchiya.naoyuki.gm@u.tsukuba.ac.jp a-kawasaki@md.tsukuba.ac.jp.ORCID http://orcid.org/0000-0002-6776-5580

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesEosinophilic granulomatosis with polyangiitis (EGPA) is classified as a subtype of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). A recent genome-wide association study (GWAS) of EGPA in populations of European ancestry reported several susceptibility loci. In view of population differences in genetic factors of AAV, we made an attempt to examine the contribution of these loci to EGPA in a Japanese population.

methodsThe EGPA-associated variants in

resultsAn increasing tendency in

conclusion

Indexed as

Churg-Strauss SyndromeGenetic Predisposition to DiseaseGranulomatosis with PolyangiitisAllelesAntibodies, Antineutrophil CytoplasmicEast Asian PeopleFemaleGene FrequencyGenome-Wide Association StudyHumansJapanMaleMiddle AgedPolymorphism, Single NucleotideWhite PeopleAntibodies, Antineutrophil CytoplasmicAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisEpidemiologyPolymorphism, GeneticVasculitis

Identifiers

PMID42431644
PMCPMC13358274

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.