ArticleJournal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus2026
Assessing visual and refractive outcomes of subretinal fluid detected by handheld swept-source optical coherence tomography in full-term newborns.
Article in Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHealthy, full-term newborns frequently present with foveal subretinal fluid (SRF), reported to spontaneously resolve within 1-4 months. The purpose of this study was to evaluate refractive and visual outcomes of SRF.
methodsIn this prospective, single-institution study, healthy full-term infants were imaged using handheld swept-source optical coherence tomography between 12-72 hours after birth. OCT macular volumes were graded for SRF and foveal immaturity parameters. Participants returned at 9 months and 5 years for visual acuity and cycloplegic refraction assessments.
resultsOf the 96 eyes (50 infants) imaged, 15 eyes (16%) of 10 infants had SRF. Eyes with SRF demonstrated greater central foveal thickness than those without SRF (202 ± 51 mm vs 149 ± 23 mm [P < 0.001]). No significant differences were found in inner or outer fovea/parafovea ratio, foveal or parafoveal choroidal thicknesses, or central neuroretinal thickness (P > 0.09). Mean spherical equivalent refraction was similar between groups at 9 months (1.71 ± 1.05 vs 1.53 ± 1.04 D [P = 0.88]; n = 29 eyes) and 5 years (0.63 ± 0.53 vs 1.79 ± 0.90 [P = 0.20]; n = 35 eyes). Mean logMAR visual acuities were similar between groups at 9 months (0.91 ± 0.36 vs 0.72 ± 0.19 [P = 0.62]) and 5 years (0.09 ± 0.12 vs 0.08 ± 0.10 [P = 0.75]).
conclusionsIn this small cohort, SRF in full-term newborns was not associated with foveal immaturity at birth or with negative refractive or visual outcomes up to 5 years. These results suggest that SRF is likely transient and benign.
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