ArticleInternational journal of radiation oncology, biology, physics2026
Postoperative Epidural Disease and Local Control After Separation Surgery and Spine Stereotactic Body Radiation Therapy.
Article in International journal of radiation oncology, biology, physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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15 authors.
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Abstract
purposeLimited data are available on outcomes of patients with spinal metastases treated with separation surgery with postoperative stereotactic body radiation therapy. METHODS AND MATERIALS: This is a retrospective cohort study of 497 patients treated for 532 lesions between 2013 and 2024. We evaluated local failure (LF) and adverse events (hardware failure [HF] requiring surgical intervention, radiation myelitis [RM], and vertebral compression fracture [VCF]). Incidences of LF, VCF, RM, and HF were analyzed considering death as a competing risk. Dosimetric variables, including minimal biologically effective dose (BED) to the clinical target volume (CTV Dmin BED10), were obtained. Preoperative and postoperative epidural spinal cord compression (ESCC) scores were calculated based on preoperative magnetic resonance imaging and postoperative myelogram simulation.
resultsMedian follow-up time among surviving patients was 74.5 months (95% CI, 70-94). Median overall survival was 14 months (95% CI, 13-17). The risk of LF (95% CI) at 1, 2, and 3 years was 7.7% (5.6%-10%), 10% (7.9%-13%), and 13% (10%-16%), respectively. At 2 years, cumulative incidences of VCF, RM, and HF requiring surgery were 2% (95% CI, 1%-3.5%), 1% (0.39%-2.3%), and 3.8% (2.4%-5.8%), respectively. On univariable and multivariable regression, CTV Dmin BED10 correlated with risk of LF (on multivariable regression, hazard ratio, 0.96; 95% CI, 0.93-0.99; P = .005). After excluding previously radiated lesions, postoperative ESCC ≤1C was associated with an approximately 2-times higher likelihood of achieving the median CTV Dmin BED10 than ESCC 2 (odds ratio, 2.06; 95% CI, 1.31-3.26; P = .002), whereas a postoperative ESCC ≤1B was not associated with higher odds of achieving the median CTV Dmin BED10 compared with ≥1C (odds ratio, 0.75; 95% CI, 0.50-1.11; P = .15).
conclusionsIn this large series of separation surgery followed by spine stereotactic body radiation therapy, local control was excellent with few adverse events. Higher CTV minimum biological dose-enabled by postoperative ESCC ≤1C-was the strongest predictor of durable local control.
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