Evidence map›Paper›PMID 42431322›Full record

ArticleJournal of affective disorders2026

Investigating functional connectivity differences during food vs. monetary reward processing across appetitive phenotypes of major depressive disorder.

Sarah L Brassard, Hyeon Min Ahn, Hilâl Cerit, Taryn Hye, E Leighton Durham, Rose S Chang, Julia Hall, Sarah Boukezzi, Jill M Goldstein, Daniel G Dillon and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sarah L BrassardDivision of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. Electronic address: slbrassard@bwh.harvard.edu.
Hyeon Min AhnDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA, USA.
Hilâl CeritDivision of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Taryn HyeDivision of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
E Leighton DurhamDivision of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Rose S ChangDivision of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Julia HallDivision of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Sarah BoukezziDivision of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Jill M GoldsteinDivision of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Mass General Brigham, Boston, MA, USA; Innovation Center on Sex Differences in Medicine, Mass General Brigham, Boston, MA, USA.
Daniel G DillonHarvard Medical School, Boston, MA, USA; Center for Depression, Anxiety and Stress Research, Belmont, MA, USA; McLean Imaging Center, McLean Hospital, Belmont, MA, USA.
Diego A PizzagalliPsychiatry & Human Behavior, School of Medicine, University of California Irvine, CA, USA; Neurobiology & Behavior, Charlie Dunlop School of Biological Sciences, University of California Irvine, CA, USA; Biomedical Engineering, The Henry Samueli School of Engineering, University of California Irvine, CA, USA; Institute for Translational Depression Discoveries, University of California Irvine, CA, USA.
Laura M HolsenDivision of Women's Health, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Psychiatry, Mass General Brigham, Boston, MA, USA.

Funding

Project 4_Bruchas : Circuit-level Approaches for Dissecting Approach/Avoidance Behaviors Mediated by Nociceptin Systems in MiceP50MH119467 · NIMH · MCLEAN HOSPITAL · PI FRANK, MICHAEL J. · 2020 to 2024
$15.9M
Aging of Emotion Circuitry: Impact of Sex, Depression, and Fetal Immune OriginsR01AG057505 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JILL M GOLDSTEIN · 2018 to 2026
$8.5M
Neuroimaging Studies of Reward Processing in DepressionR37MH068376 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI Diego A Pizzagalli · 2016 to 2026
$7.4M
Ghrelin Modulation of Mesolimbic Reward Signaling in Stress-induced HyperphagiaR01DK104772 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI HOLSEN, LAURA MCGRATH · 2016 to 2020
$2.7M
NIA NIH HHS R01 AG057505NIDDK NIH HHS R01 DK104772NIMH NIH HHS P50 MH119467NIMH NIH HHS R37 MH068376Wellcome Trust
6 · The paper itself

Abstract

Reward processing deficits are prominent in major depressive disorder (MDD) and contribute to appetitive phenotypes: hyperphagic (HyperMDD) and hypophagic (HypoMDD). However, few studies have examined neurobiological processes underlying these phenotypes, and whether they stem from aberrant responsivity specific to food or rewards more broadly. This study probed group differences in functional connectivity during anticipation and outcome phases of food vs. monetary rewards across appetitive MDD phenotypes. 14 unmedicated HyperMDDs, 20 unmedicated HypoMDDs, and 36 healthy controls completed food and monetary incentive delay tasks while undergoing fMRI. Psychophysiological interaction analyses examined functional connectivity changes during relevant task conditions/reward processing components: anticipation, successful reward outcome, and failed reward outcomes. Findings revealed dissociable patterns of fronto-striatal and salience network connectivity during anticipatory reward processing among groups, reflecting differential top-down control of food versus monetary cues. HypoMDD was associated with heightened connectivity to food cues and negative connectivity to monetary cues, while HyperMDD exhibited the opposite patterns. MDD groups also differed in connectivity during reward outcome: HypoMDD demonstrated increased functional connectivity for successful food outcome and reduced functional connectivity for successful money outcome whereas HyperMDD demonstrated reduced connectivity during successful food outcome and increased connectivity during successful money reward outcome. For failed reward outcomes, only HyperMDD demonstrated reduced connectivity for failed food outcomes, and increased connectivity for failed money outcomes. These findings suggest that appetitive MDD phenotypes are distinguished by opposing circuitry profiles that bias responsivity toward food versus monetary rewards, patterns that may help guide the development of phenotype- and reward-specific interventions.

Indexed as

Appetitive BehaviorBrainFoodHyperphagiaMajor Depressive DisorderRewardAdultAnticipation, PsychologicalCuesFemaleHumansMagnetic Resonance ImagingMaleMotivationNeural PathwaysPhenotypeFood incentive delayFunctional connectivityHyperphagiaHypophagiaMajor depressive disorderMonetary incentive delayReward processing

Identifiers

PMID42431322
PMCPMC13455718

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.