ArticleJCO precision oncology2026
Endometrial Cancer by ERBB2 Amplification (ERBB2amp) Status: Differences in Molecular Subtypes, Ancestry, and Real-World Outcomes.
Article in JCO precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeEndometrial cancer (EC) has rising mortality rates and persistent racial disparities, particularly among non-Hispanic Black women who are more likely to present with aggressive histologic subtypes associated with worse survival.
methodsWe analyzed 16,073 patients with EC who underwent tissue comprehensive genomic profiling via Foundation Medicine. Genetic ancestry was inferred using a single nucleotide polymorphism-based classifier. An outcomes cohort of 1,275 patients with advanced or recurrent EC from the Flatiron Health-Foundation Medicine CGDB was used to assess survival outcomes. Patients receiving human epidermal growth factor receptor 2 (HER2)-targeted therapy were excluded from the overall survival (OS) analysis.
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