ArticleScience advances2026
Epigenetic landscape, key transcriptional regulators, and in vivo identification of human Tr1 cells.
Alma-Martina Cepika, Laura Amaya, Colin Waichler, Mansi Narula, Michelle Mantilla, Benjamin C Thomas, Pauline P Chen, Robert A Freeborn, Mara Pavel-Dinu, Jason Nideffer and 6 more
Abstract read
In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
16 authors.
Alma-Martina CepikaDivision of General Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-2862-1901 Laura AmayaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-8742-9111 Colin WaichlerDivision of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0009-0007-5201-6724 Mansi NarulaDivision of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-5148-7256 Michelle MantillaDivision of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0009-0006-8764-3245 Benjamin C ThomasDivision of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-6692-9558 Pauline P ChenDivision of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-4730-3370 Robert A FreebornDivision of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-0599-9442 Mara Pavel-DinuDivision of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-2719-2498 Jason NidefferDivision of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-4421-8656 Matthew PorteusDivision of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-3850-4648 Rosa BacchettaDivision of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-0606-6268 Fabian MüllerIntegrative Cellular Biology and Bioinformatics, Saarland University, Saarbrücken, Germany.ORCID 0000-0001-5809-2321 William J GreenleafDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1409-3095 Howard Y ChangInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-9459-4393 Maria Grazia RoncaroloDivision of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1636-1495 Funding
Center for Personal Dynamic RegulomesRM1HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2019 to 2023
$13.8MUltra high throughput sequencer for sustaining and enhancing multi-scale genomic studiesS10OD025212 · OD · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2018 to 2018
$600kComputer ClusterS10OD021763 · OD · STANFORD UNIVERSITY · PI JI, HANLEE P · 2016 to 2016
$481kNHGRI NIH HHS RM1 HG007735NIH HHS S10 OD021763NIH HHS S10 OD025212
6 · The paper itselfAbstract
Type 1 regulatory T (Tr1) cells are CD4
Indexed as
Epigenesis, GeneticGene Expression RegulationT-Lymphocytes, RegulatoryAnimalsBasic-Leucine Zipper Transcription FactorsCell DifferentiationGene Expression ProfilingHumansInterferon Regulatory Factor-4Interferon Regulatory FactorsMiceProto-Oncogene Proteins c-mafBasic-Leucine Zipper Transcription FactorsBATF protein, humanInterferon Regulatory Factor-4Interferon Regulatory FactorsMAF protein, humanProto-Oncogene Proteins c-maf
Identifiers
PMID42430483
PMCPMC13353415
What OpenQuestion holds
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