ArticleScience advances2026
Low-intensity stimulation drives macrophage efferocytosis via ACSL4 lipid remodeling and CCL9-CCR1 signaling for tendon-bone healing.
Juncheng Yao, Yuhao Wu, Xuan Wang, Jiexin Zhang, Yan Shao, Huabin Chen, Haiyan Zhang, Haobin Li, Jianying Pan, Yitao Zhao and 3 more
Abstract read
In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
13 authors.
Juncheng YaoDepartment of Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0001-9490-4577 Yuhao WuDepartment of Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.ORCID 0009-0008-7564-1458 Xuan WangDepartment of Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0002-8809-6574 Jiexin ZhangDepartment of Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0001-7132-8247 Yan ShaoDepartment of Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Huabin ChenDepartment of Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Haiyan ZhangDepartment of Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Haobin LiDepartment of Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Jianying PanDepartment of Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Yitao ZhaoDepartment of Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0001-9889-5559 Daozhang CaiDepartment of Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0003-2294-5411 Denghui XieDepartment of Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0001-5414-3152 Chun ZengDepartment of Sports Medicine, Center for Orthopedic Surgery, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.ORCID 0000-0002-5682-1452 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The mechanisms underlying exercise rehabilitation-induced tendon-bone healing remain unclear. Using a mouse model of anterior cruciate ligament reconstruction, we found that low-intensity mechanical stimulation promoted macrophage M2 polarization, phagocytosis, and efferocytosis at the tendon-bone interface via acyl-CoA synthetase long-chain family member 4 (ACSL4)-mediated lipid metabolism reprogramming.
Indexed as
Bone and BonesCoenzyme A LigasesLipid MetabolismMacrophagesSignal TransductionTendonsWound HealingAnimalsEfferocytosisLong-Chain-Fatty-Acid-CoA LigaseMicePhagocytosisCoenzyme A LigasesLong-Chain-Fatty-Acid-CoA Ligase
Identifiers
PMID42430473
PMCPMC13353419
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