Evidence map›Paper›PMID 42430471›Full record

ArticleScience advances2026

G protein selectivity in group I metabotropic glutamate receptors.

Yue Lu, Tianlei Wen, Xuhang Lu, Guimin Zhang, Tingting Meng, Tianjin Liu, Xinyan Wang, Yuequan Shen, Xue Yang

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yue LuState Key Laboratory of Medicinal Chemical Biology and Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300350, China.ORCID 0009-0003-4911-5765
Tianlei WenState Key Laboratory of Medicinal Chemical Biology and Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300350, China.ORCID 0000-0001-5321-0093
Xuhang LuMedical Research Center, Shaoxing People's Hospital, Shaoxing 312000, China.ORCID 0000-0003-3677-0333
Guimin ZhangState Key Laboratory of Medicinal Chemical Biology and Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300350, China.ORCID 0009-0007-7791-3608
Tingting MengState Key Laboratory of Medicinal Chemical Biology and Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300350, China.ORCID 0009-0007-9391-6294
Tianjin LiuState Key Laboratory of Medicinal Chemical Biology and Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300350, China.
Xinyan WangState Key Laboratory of Medicinal Chemical Biology and Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300350, China.ORCID 0009-0005-7692-1003
Yuequan ShenState Key Laboratory of Medicinal Chemical Biology and Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300350, China.ORCID 0000-0002-3775-0900
Xue YangState Key Laboratory of Medicinal Chemical Biology and Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300350, China.ORCID 0000-0002-4960-0950

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabotropic glutamate (mGlu) receptors are class C G protein-coupled receptor involved in synaptic transmission and neurological disorders. Group I mGlu receptors (mGlu1 and mGlu5) predominantly couple to G

Indexed as

GTP-Binding ProteinsReceptors, Metabotropic GlutamateAllosteric RegulationAnimalsCryoelectron MicroscopyGlutamic AcidGTP-Binding Protein alpha Subunits, Gq-G11HumansModels, MolecularProtein BindingProtein ConformationGlutamic AcidGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Proteinsmetabotropic glutamate receptor type 1Receptors, Metabotropic Glutamate

Identifiers

PMID42430471
PMCPMC13353412

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.