Evidence map›Paper›PMID 42430404›Full record

ArticlePloS one2026

Measuring airway compliance of pulmonary fibrosis by endobronchial optical coherence elastography.

Hang Xu, Jian-Yi Niu, Zi-Qing Zhou, Li-Ya Lu, Chun-Li Tang, Yang-Huan Chen, Shi-Yue Li, Ye Gu, Yu Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hang XuDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, Guangdong, China.ORCID https://orcid.org/0009-0000-1428-8373
Jian-Yi NiuDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, Guangdong, China.
Zi-Qing ZhouDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, Guangdong, China.
Li-Ya LuDepartment of Anesthesiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Chun-Li TangDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, Guangdong, China.
Yang-Huan ChenDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, Guangdong, China.
Shi-Yue LiDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, Guangdong, China.
Ye GuDepartment of Endoscopy Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Yu ChenDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOptical coherence elastography derived from optical coherence tomography for measuring soft tissue and organ compliance, holds promise in respirology but remains largely exploratory.

methodsThe airway lumen area (Ai) was measured by endobronchial optical coherence tomography in control subjects (n = 4), and pulmonary fibrosis (n = 8) while airway pressure (Paw) increased from 0-20 cm H2O. Airway compliance (AC) and airway specific compliance (ASC) were derived from the Paw vs. Ai curves. Evaluate correlations among Ai, AC, ASC, and lung function parameters.

resultsEndobronchial optical coherence elastography (EB-OCE) was constructed by ASC, which could detect AC and ASC among 3rd to 7th generations of bronchi. Pulmonary fibrosis tended to exhibit lower ASC in 5th to 7th generations of bronchi compared to controls. The ASC-7 appeared to be positively correlated with FEV₁, FVC, TLC, VC, and DLCO.

conclusionsEB-OCE provides a novel approach to measure AC and extends the analysis to small airway. Pulmonary fibrosis appeared to show a heterogeneous reduction in AC across different bronchial generations compared to controls. A decline in ASC-7 was possibly associated with reduced lung function.

Indexed as

BronchiElasticity Imaging TechniquesPulmonary FibrosisTomography, Optical CoherenceAgedFemaleHumansLung ComplianceMaleMiddle Aged

Identifiers

PMID42430404
PMCPMC13354069

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.