Evidence map›Paper›PMID 42430092›Full record

ArticleDigestive diseases and sciences2026

Impact of Diet and Body Mass Index on the Development of Pouchitis in the First Year After Ileal Pouch-Anal Anastomosis.

Sophia Goldbeck, Chelsea Anderson, Jennifer Barr, Jordan Axelrad, Millie D Long, Hans H Herfarth, Edward Barnes

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Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Sophia GoldbeckUniversity of North Carolina School of Medicine, Chapel Hill, NC, USA.
Chelsea AndersonCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.
Jennifer BarrCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.
Jordan AxelradDepartment of Medicine, New York University Grossman School of Medicine, New York, NY, USA.
Millie D LongCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.
Hans H HerfarthCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.
Edward BarnesCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA. edward_barnes@med.unc.edu.ORCID https://orcid.org/0000-0001-9894-8796

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
Treatment Approaches and Outcomes in Pouch-related Disorders after Colectomy for Ulcerative ColitisK23DK127157 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARNES, EDWARD · 2021 to 2025
$1.0M
NIDDK NIH HHS K23DK127157NIDDK NIH HHS P30DK034987NIDDK NIH HHS T35-DK007386
6 · The paper itself

Abstract

backgroundAlthough pouchitis is the most common complication after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis (UC), the influence of diet on pouchitis is poorly understood. Thus, evidence-based dietary recommendations after IPAA are limited.

aimsWe evaluated dietary intake in the period after the final stage of IPAA for UC and Body Mass Index (BMI) to identify potential associations with pouchitis.

methodsWe used the Dietary Screener Questionnaire (DSQ) to assess dietary intake among patients in a prospective cohort enrolled within 2 weeks of the final stage of IPAA for UC. We compared food group and fiber intake of those who developed pouchitis within 12 months of the final stage of IPAA with those who did not. These were also compared to the United States Department of Agriculture (USDA) recommended daily goals.

resultsAmong 89 patients, there was no significant difference in individual fiber intake when comparing those who developed pouchitis and those who did not. In comparison with USDA guidelines, both groups (pouchitis and no pouchitis) exhibited decreased intake of several food groups, such as fruits, vegetables, fiber, and dairy. Patients who developed pouchitis had a significantly higher median body mass index (BMI) at the time of surgery compared to patients who did not develop pouchitis (median 29.2 vs. 24.8, P = 0.022).

conclusionsIn a prospective cohort, we identified no association between dietary intake and development of pouchitis within the first year after IPAA. However, elevated BMI may represent a unique target for intervention to prevent pouchitis occurrence.

Indexed as

Body Mass IndexColitis, UlcerativeDietPouchitisProctocolectomy, RestorativeAdultDietary FiberFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsTime FactorsDietary FiberBody mass indexDietObesityPouchitisUlcerative colitis

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.