Evidence map›Paper›PMID 42430059›Full record

ArticleIndian journal of pediatrics2026

Normal Reference Range of the Urinary Calcium/Creatinine Ratio in Healthy Children.

Vaibhav D Lokhande, Vaishali S Patil, Suhas P Kulkarni

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Article in Indian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

3 authors.

Vaibhav D LokhandeDepartment of Biochemistry, D. Y. Patil Medical College, D.Y. Patil Education Society (Deemed to be University), Kolhapur, India.
Vaishali S PatilDepartment of Biochemistry, D. Y. Patil Medical College, D.Y. Patil Education Society (Deemed to be University), Kolhapur, India. shalipatil2003@gmail.com.
Suhas P KulkarniDepartment of Pediatrics, D. Y. Patil Medical College, D.Y. Patil Education Society (Deemed to be University), Kolhapur, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo establish age-specific normal reference range for urinary calcium-to-creatinine ratio (UCa/Cr) in healthy children aged 7-12 y from urban Kolhapur.

methodsA total of 358 children was enrolled after obtaining ethical approval and parental consent. Second-morning, non-fasting urine samples were collected in a sterile, labelled container for analysing urinary calcium by the Cresolpthalein complexone spectrophotometric method and urinary creatinine by Modified Jaffe's method.

resultsThe mean urinary calcium-to-creatinine ratio across different age groups ranged from 0.12 ± 0.08 mg/mg at age 7 to 0.09 ± 0.02 mg/mg at age 12 y, with the highest value observed at age 8 (0.15 ± 0.05 mg/mg). The normal reference range for urinary calcium-to-creatinine ratio in this population was found to be 0.05 ± 0.192 mg/mg. These findings are consistent with previous studies showing a decline in urinary calcium-to-creatinine ratio with age, likely due to hormonal changes and increased calcium absorption during puberty.

conclusionsEstablishing population-specific reference values is crucial for accurate diagnosis of hypercalciuria and related disorders in children. This study provides valuable data for clinical practice in the Kolhapur region, aiding in the early detection and management of calcium metabolism disorders in children.

Indexed as

CalciumCreatinineChildFemaleHumansIndiaMaleReference ValuesCalciumCreatinineHypercalciuriaUrinary calciumUrinary calcium-to-creatinine ratioUrinary creatinine

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