Evidence map›Paper›PMID 42430036›Full record

ArticleJournal of cardiovascular translational research2026

The Role of miR-501-3p in Abdominal Aortic Aneurysm Progression: A Pilot Study.

Hiroki Mine, Kensuke Toyama, Kenshi Yoshimura, Ryotaro Nagashima, Shinji Miyamoto, Kasumi Tsunoda, Yasunori Abe, Markus U Wagenhäuser, Joscha Mulorz, Joshua M Spin and 1 more

Abstract read
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Article in Journal of cardiovascular translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hiroki MineDivision of Cardiovascular Surgery, Department of Surgery, Kurume University School of Medicine, 67 Asahi, Kurume, Fukuoka, 830-0011, Japan.
Kensuke ToyamaDivision of Cardiovascular Surgery, Department of Surgery, Kurume University School of Medicine, 67 Asahi, Kurume, Fukuoka, 830-0011, Japan. one.of.ken@icloud.com.ORCID 0000-0002-3959-4737
Kenshi YoshimuraDepartment of Cardiovascular Surgery, Oita University Hospital, Yufu, Oita, Japan.
Ryotaro NagashimaDepartment of Cardiovascular Surgery, Oita University Hospital, Yufu, Oita, Japan.
Shinji MiyamotoDepartment of Cardiovascular Surgery, Oita University Hospital, Yufu, Oita, Japan.
Kasumi TsunodaDivision of Cardiovascular Surgery, Department of Surgery, Kurume University School of Medicine, 67 Asahi, Kurume, Fukuoka, 830-0011, Japan.
Yasunori AbeDivision of Cardiovascular Surgery, Department of Surgery, Kurume University School of Medicine, 67 Asahi, Kurume, Fukuoka, 830-0011, Japan.
Markus U WagenhäuserDepartment of Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
Joscha MulorzDepartment of Vascular and Endovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
Joshua M SpinVA Palo Alto Health Care System, Palo Alto, CA, USA.
Eiki TayamaDivision of Cardiovascular Surgery, Department of Surgery, Kurume University School of Medicine, 67 Asahi, Kurume, Fukuoka, 830-0011, Japan.

Funding

JSPS Grant-in-Aid for Scientific Research 20K07805JSPS Grant-in-Aid for Scientific Research 23K08258JSPS Grant-in-Aid for Scientific Research 26K11740
6 · The paper itself

Abstract

MiR-501-3p, a small non-coding RNA, has been linked to vascular damage and arterial stiffness, but its role in abdominal aortic aneurysm (AAA) remains unknown. Blood exosomal microRNAs were extracted, and RNA was also extracted from tissue samples, including both the region of maximum aortic dilation and the transition zone between normal and aneurysmal tissue. The low blood miR-501-3p expression group included more AAA patients and greater size than the high group. Multivariate analysis revealed a significant association between the presence of AAA and low blood miR-501-3p (OR = 6.467, p < 0.05). In AAA tissue, miR-501-3p was lower in the maximum point compared to the border point and correlated with larger AAA sizes. All low expression cases at the maximum point had an AAA ≥ 55 mm, whereas only 9.5% of cases in the high expression group had an AAA ≥ 55 mm (P < 0.01). miR-501-3p was identified as a potential key indicator and regulator of AAA presence and expansion.

Indexed as

Aorta, AbdominalAortic Aneurysm, AbdominalCirculating MicroRNAMicroRNAsAgedDilatation, PathologicDisease ProgressionExosomesFemaleHumansMaleMiddle AgedPilot ProjectsRisk FactorsCirculating MicroRNAMicroRNAsAbdominal aortic aneurysmBlood exosomeMiR-501-3p

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.