Evidence map›Paper›PMID 42429950›Full record

ReviewAnnals of hematology2026

Evaluation of non-opioid therapies for pain management of sickle cell disease: a literature-based review.

Kayla Riley, Rolake Neba, Adenike Atanda

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kayla RileyOsteopathic Medicine Student OMS III, Texas College of Osteopathic Medicine, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107, USA.
Rolake NebaDepartment of Pharmacotherapy, UNT System College of Pharmacy, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107, USA.ORCID http://orcid.org/0000-0002-7348-6369
Adenike AtandaDepartment of Pharmacotherapy, UNT System College of Pharmacy, 3500 Camp Bowie Blvd, Fort Worth, TX, 76107, USA. Adenike.atanda@unthealth.edu.ORCID http://orcid.org/0000-0001-5905-9099

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pain is a debilitating complication of sickle cell disease (SCD), driven by recurrent vaso-occlusive crises and chronic pain syndromes involving central sensitization and neuropathic mechanisms. Although opioid medications remain first-line therapy for acute pain, there are limitations that highlight the need for effective adjunctive approaches. Available data support non-opioid pharmacologic therapies including acetaminophen and nonsteroidal anti-inflammatory drugs as components of multimodal analgesia, with emerging evidence for therapies targeting neuropathic and centralized pain. Non-pharmacologic interventions such as cognitive behavioral therapy have also demonstrated potential benefits as adjunctive strategies in SCD pain management. This literature review examines evidence supporting non-opioid pharmacologic and non-pharmacologic therapies for pain management in SCD and is based on structured searches of PubMed, MEDLINE, and Cochrane databases.

Indexed as

Analgesics, Non-NarcoticAnemia, Sickle CellChronic PainPain ManagementAcetaminophenAnti-Inflammatory Agents, Non-SteroidalCognitive Behavioral TherapyHumansVaso-Occlusive CrisesAcetaminophenAnalgesics, Non-NarcoticAnti-Inflammatory Agents, Non-SteroidalAcetaminophenAcupunctureAcute painCBTChronic painKetamineMultimodal analgesiaNon-opioidNSAIDOpioidSickle cell diseaseVaso-occlusive crisis

Identifiers

PMID42429950
PMCPMC13635015

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.