Evidence map›Paper›PMID 42429941›Full record

ArticleCellular and molecular life sciences : CMLS2026

The formin Fhod3 is required for sarcomere reassembly after mitosis in postnatal cardiomyocytes.

Shuhei Sakaguchi, Yohko Kage, Eka Adip Pradipta, Ayako Miura, Koji Furukawa, Ryu Takeya

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuhei Sakaguchi *Department of Pharmacology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Japan.
Yohko Kage *Department of Pharmacology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Japan.
Eka Adip PradiptaDepartment of Pharmacology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Japan.
Ayako MiuraDepartment of Pharmacology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Japan.
Koji FurukawaDepartment of Cardiovascular Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Japan.
Ryu TakeyaDepartment of Pharmacology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Japan. takeya@med.miyazaki-u.ac.jp.ORCID http://orcid.org/0000-0002-9987-1513

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fhod3, a member of the formin family of proteins that regulate actin polymerization, is essential for the organization of cardiac sarcomeres during embryonic cardiogenesis. We previously demonstrated that the perinatal deletion of Fhod3 in mice results in lethality with disorganized sarcomeres, whereas the deletion in the adult period is non-lethal and does not affect sarcomere morphology. To clarify the underlying mechanism of this developmental stage-dependent outcome, we examined the effects of Fhod3 depletion in primary cultured cardiomyocytes derived from Fhod3

Indexed as

Microfilament ProteinsMitosisMyocytes, CardiacSarcomeresAnimalsAnimals, NewbornCells, CulturedForminsMiceFhod3 protein, mouseForminsMicrofilament ProteinsActinCell cycleHeartMyofibrilPolymerization factor

Identifiers

PMID42429941
PMCPMC13638912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.