Evidence map›Paper›PMID 42429891›Full record

ArticleOral and maxillofacial surgery2026

Evaluation of pre and postoperative inflammatory biomarkers through proximity extension assay in tongue squamous cell carcinoma : a pilot study.

Nanae Yatagai, Akira Kimoto, Junya Yamashita, Yui Enomoto, Yumi Muraki, Takumi Hasegawa, Masaya Akashi

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Article in Oral and maxillofacial surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Nanae YatagaiDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Akira KimotoDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. akimoto@med.kobe-u.ac.jp.ORCID https://orcid.org/0000-0001-8757-0943
Junya YamashitaDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Yui EnomotoDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Yumi MurakiDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Takumi HasegawaDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Masaya AkashiDepartment of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Funding

Japan Society for the Promotion of Science 21K10138
6 · The paper itself

Abstract

backgroundAlthough prognostic biomarkers in patients with oral squamous cell carcinoma (SCC) have previously been explored, none have yet been established for clinical use for oral SCC. This study evaluated plasma inflammatory cytokines using the proximity extension assay (PEA) in patients with tongue SCC before and after surgery to investigate relationships between disease status and cytokine levels.

methodsPlasma samples from 19 patients who underwent surgery for tongue SCC were collected pre- and postoperatively. Inflammatory cytokine levels were quantified by PEA. Cytokine levels were compared between preoperative patients with early- and advanced-stage cancer, patients with recurrence after surgery and with no recurrence, and as well as between patients of each stage grouped by prognosis.

resultsNo difference in preoperative cytokine levels was found between early- and advanced-stage patients. Levels of fms-related receptor tyrosine kinase 3 ligand (FLT3LG) were significantly lower in the postoperative recurrent group as compared with the nonrecurrent group (p = 0.049). Amongst the advanced-stage patients with recurrence or metastasis in postoperative, the reduction in interleukin-6 (IL-6), hepatocyte growth factor (HGF), and tumor necrosis factor (TNF) levels following surgery was less pronounced compared with the patients with no evidence of disease. (IL-6: p = 0.037, HGF: p = 0.020, TNF: p = 0.037).

conclusionsThis pilot study indicates that FLT3LG, IL-6, HGF, and TNF may serve as promising biomarker candidates for evaluating disease status and prognosis in patients with tongue SCC using PEA technology, though validation in larger and adequately powered cohorts is warranted.

Indexed as

Biomarkers, TumorCarcinoma, Squamous CellCytokinesTongue NeoplasmsAdultAgedFemaleHepatocyte Growth FactorHumansInterleukin-6MaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPilot ProjectsPostoperative PeriodBiomarkers, TumorCytokinesHepatocyte Growth FactorInterleukin-6Inflammatory cytokinePlasma biomarkerProximity extension assaySquamous cell carcinomaTongue

Identifiers

PMID42429891

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