ArticleJACC. Clinical electrophysiology2026
Beta-Blockers and Exercise Performance in Children With Long QT Syndrome.
Article in JACC. Clinical electrophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
backgroundYoung people taking beta-blockers for long QT syndrome (LQTS) have concerns about exercise performance.
objectivesThis study sought to determine whether objective measures of cardiopulmonary fitness are influenced by beta-blocker dose in LQTS.
methodsIn a retrospective chart review of treadmill cardiopulmonary exercise tests (CPETs), we measured peak oxygen consumption (Vo
resultsWe evaluated 220 CPETs in 93 patients with LQTS. The mean age at first CPET was 12 ± 3.9 years. In multivariable analysis, %PHR decreased by 13% for every 1 mg/kg/d increase in beta-blocker dose, demonstrating physiologic beta-blocker effects. However, we identified no correlation between nadolol dose and measures of cardiopulmonary fitness. Neither peak Vo
conclusionsIn children with LQTS, we did not observe any relationship between higher nadolol doses and objective measures of effort (peak RER) or cardiopulmonary fitness (peak Vo
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