ArticleMicrobiology spectrum2026
Emergence of ceftazidime-avibactam resistance mediated by KPC variants KPC-71 and KPC-78 in ST463
Fengjiao Yang, Yingbo Sun, Wenxia Chen, Dandan Shen, Jichao Zhu, Zijiu Sun, Yufei Cai, Yue Zhang, Hui Shen, Fenyong Sun and 3 more
Abstract read
In one paragraphArticle in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Fengjiao Yang *Department of Clinical Laboratory, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-7305-9367 Yingbo Sun *Department of Central Laboratory, Clinical Medicine Scientific and Technical Innovation Park, Shanghai Tenth People's Hospital, Shanghai, China.ORCID 0009-0007-2710-5303 Wenxia Chen *Department of Clinical Laboratory, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.
Dandan ShenDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Jichao ZhuFifth School of Clinical Medicine of Zhejiang Chinese Medical University and Affiliated Central Hospital of Huzhou University, Huzhou Central Hospital, Huzhou, China.
Zijiu SunDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yufei CaiBaishan Annie Wright Schools, Qingdao, Shandong, China.
Yue ZhangDepartment of Central Laboratory, Clinical Medicine Scientific and Technical Innovation Park, Shanghai Tenth People's Hospital, Shanghai, China.
Hui ShenDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-7456-5536 Fenyong SunDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yanghua XiaoDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.ORCID 0000-0001-7417-0799 Cizhong JiangDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China.ORCID 0000-0001-5406-2360 Zhongqi CuiDepartment of Clinical Laboratory, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.ORCID 0000-0002-2438-442X Funding
Innovation Group Project of Shanghai Municipal Health Commission 2019CXJQ03National Natural Science Foundation of China 82372701National Natural Science Foundation of China 82402720Natural Science Foundation of Shanghai Municipality 24ZR1457300
6 · The paper itselfAbstract
IMPORTANCE: In this study, we report the detection of the uncommon KPC variants KPC-71 and KPC-78 in clinical sequence type 463 (ST463) carbapenem-resistant CLINICAL TRIALS: This study is registered with ClinicalTrials.gov as ChiCTR2500105846.
Indexed as
Anti-Bacterial AgentsAzabicyclo CompoundsBacterial Proteinsbeta-LactamasesCeftazidimeDrug Resistance, Multiple, BacterialPseudomonas aeruginosaDrug CombinationsHumansMaleMicrobial Sensitivity TestsPseudomonas InfectionsThird Generation CephalosporinsWhole Genome SequencingAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsBacterial Proteinsbeta-LactamasesCeftazidimeDrug CombinationsThird Generation Cephalosporinsceftazidime-avibactam resistanceCRPAKPC-71KPC-78ST463
Identifiers
PMID42429474
PMCPMC13436407
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