Observational studyTherapeutic advances in respiratory disease
Hypercapnia is associated with an increased risk of ICU admission and reduced inflammatory responses in AECOPD patients with severe pneumonia.
Observational study in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHypercapnia is linked to a poor prognosis in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and severe community-acquired pneumonia (SCAP), and reduced early anti-inflammatory capacity in SCAP. However, its impact on AECOPD+SCAP patients remains unclear.
objectivesTo assess hypercapnia's effects on inflammatory responses and short-term outcomes in AECOPD+SCAP patients.
designThis retrospective, dual-center study included 185 hospitalized AECOPD+SCAP patients from January 2014 to June 2025.
methodsPatients were stratified by PaCO
resultsThe three groups had similar invasive mechanical ventilation needs and in-hospital and 30-day mortality. Hypercapnic patients (especially with acidosis) had a higher intensive care unit (ICU) admission risk than normocapnic patients. The hypercapnia group had lower PCT, CRP and lactate levels versus the hypocapnia group (
conclusionHypercapnia in AECOPD+SCAP patients could indicate higher ICU admission risk (especially in cases of acidosis) and impaired early anti-inflammatory responses, which are largely independent of acidosis. The combination of hypercapnia, RDW-CV, PaO
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