Evidence map›Paper›PMID 42429287›Full record

ArticlePrenatal diagnosis2026

Natural History of Fetal Non-Nuchal Lymphatic Malformations: A Single Center Retrospective Study.

Yada Kunpalin, Dilkash Kajal, Lennart Van der Veeken, David Chitayat, Manuel Carcao, Paolo Campisi, Greg Ryan, Shiri Shinar, Tim Van Mieghem

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prenatal diagnosis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yada KunpalinDepartment of Obstetrics and Gynecology, Fetal Medicine Unit, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-7388-1414
Dilkash KajalDivision of Abdominal Imaging, Joint Department of Medical Imaging, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Lennart Van der VeekenDepartment of Obstetrics and Gynecology, Fetal Medicine Unit, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
David ChitayatDepartment of Obstetrics and Gynecology, Prenatal Diagnosis and Medical Genetics Program, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0003-1944-7294
Manuel CarcaoDivision of Haematology and Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0001-5350-1763
Paolo CampisiDepartment of Otolaryngology-Head & Neck Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Greg RyanDepartment of Obstetrics and Gynecology, Fetal Medicine Unit, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
Shiri ShinarDepartment of Obstetrics and Gynecology, Fetal Medicine Unit, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0001-6352-4846
Tim Van MieghemDepartment of Obstetrics and Gynecology, Fetal Medicine Unit, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo document the natural history and complications of second- and third-trimester non-nuchal lymphatic malformations (LM) and identify predictors of these complications.

methodsWe conducted a single-centre retrospective review of fetuses diagnosed with LMs between January 2015 and January 2024. Lesion size was quantified using the lymphatic malformation volume ratio (LVR): LVR = 0.523 x width x length x height (cm

resultsEighteen cases were included (10 cervical, 8 axillary). Uncomplicated cervical LMs grew at 0.3 cm

conclusionHigher LVR predicts haemorrhage and airway intervention in cervical LMs, and delivery complications in axillary LMs. These exploratory observations warrant confirmation in larger prospective cohorts.

Indexed as

Lymphatic AbnormalitiesAdultFemaleHumansPregnancyRetrospective StudiesUltrasonography, Prenatalfetal therapyfetal tumorlymphangiomalymphatic malformationMRIprenatalultrasonography

Identifiers

PMID42429287
PMCPMC13446536

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.