Evidence map›Paper›PMID 42429200›Full record

ArticleDevelopmental neurobiology2026

Zika Virus Inoculation During Pregnancy Impaired Maternal Care and Altered Prolactin and Corticosterone Levels in Rats.

Meirylanne Gomes-da-Costa, Adriana Souza Dos Santos, Anna Luísa Lothhammer Bohn, Bruna Carolina de Castro Saturnino, Gabrielle Batista de Aguiar, Gabriela Barth Jacobs, Chris Krebs Danilevicz, Ana Paula Muterle Varela, Thais Fumaco Teixeira, Paulo Michel Roehe and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Meirylanne Gomes-da-CostaPrograma de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Adriana Souza Dos SantosPrograma de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Anna Luísa Lothhammer BohnDepartamento de Ciências Morfológicas, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Bruna Carolina de Castro SaturninoPrograma de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Gabrielle Batista de AguiarPrograma de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Gabriela Barth JacobsDepartamento de Ciências Morfológicas, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Chris Krebs DanileviczDepartamento de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Ana Paula Muterle VarelaDepartamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Thais Fumaco TeixeiraDepartamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Paulo Michel RoeheDepartamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Lenir Orlandi PereiraPrograma de Pós-Graduação em Neurociências, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

Funding

CNPq-Proc. 405128/2021-5Conselho Nacional de Desenvolvimento Científico e TecnológicoConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq-Brazil)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 405128/2021-5Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES-Brazil)Fundação de Amparo à Pesquisa do Estado do Rio Grande do SulFundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS-Brazil)
6 · The paper itself

Abstract

Zika virus (ZIKV) is an Orthoflavivirus known for its teratogenicity and for causing congenital Zika syndrome (CZS) in the offspring, but recent studies suggest a negative impact on maternal brain health and behavior following gestational ZIKV inoculation. This behavior, crucial for the offspring's neurodevelopment, is regulated by the hypothalamic-pituitary-adrenal (HPA) axis and prolactin. This study investigated the effect of gestational ZIKV inoculation on maternal care in Wistar rats and its relationship with prolactin and corticosterone levels. Fifty-six females were inoculated intraperitoneally on gestational day 9 (G9) with ZIKV (28 ZK group) or vehicle (28 CT group). Blood and hypothalamus samples from a set of these animals (n = 16/group) were collected 24 h postpartum to quantify corticosterone and prolactin levels by ELISA. Maternal behavior was evaluated on postnatal days 4 and 8 (n = 12/group). ZK rats demonstrated impaired maternal care compared to CT rats. Furthermore, 24 h postpartum, ZK rats had significantly lower levels of serum and hypothalamic corticosterone, and serum prolactin. The findings suggest that gestational ZIKV inoculation compromises maternal behavior in Wistar rats, concomitant with an alteration in the hormonal profile in the immediate postpartum period. The study is pioneering in demonstrating that ZIKV affects crucial components for the regulation of maternal behavior, reinforcing the need for further research to elucidate the mechanism in the maternal brain and develop targeted therapies.

Indexed as

CorticosteroneMaternal BehaviorPregnancy Complications, InfectiousProlactinZika Virus InfectionAnimalsDisease Models, AnimalFemaleHypothalamusPregnancyRatsRats, WistarZika VirusCorticosteroneProlactincortisoldamsgestational ZIKV inoculationHPA axis

Identifiers

PMID42429200
PMCPMC13352443

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.