Evidence map›Paper›PMID 42429158›Full record

ReviewMolecular medicine reports2026

A‑Raf: A serine/threonine protein kinase with important biological functions (Review).

Muhan Yang, Mengying Chen, Jinmei Wei, Yanling Li, Chen Long, Yan Lei, Yanhong Zhou

Abstract readReview
In one paragraph

Review in Molecular medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Muhan YangDepartment of Blood Transfusion, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University/Hunan Cancer Hospital, Changsha, Hunan 410013, P.R. China.
Mengying ChenMedical Record Management and Information Statistics Center, Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
Jinmei WeiCancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410011, P.R. China.
Yanling LiDepartment of Nuclear Medicine, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, Hunan 410013, P.R. China.
Chen LongDepartment of General Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, P.R. China.
Yan LeiDepartment of Blood Transfusion, The Affiliated Cancer Hospital of Xiangya School of Medicine Central South University/Hunan Cancer Hospital, Changsha, Hunan 410013, P.R. China.
Yanhong ZhouCancer Research Institute, Basic School of Medicine, Central South University, Changsha, Hunan 410011, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A‑Raf is a serine/threonine protein kinase that belongs to the RAF kinase family. A‑Raf serves key roles in various physiological and pathological processes, including cell cycle regulation, apoptosis, material transport and metabolism, embryonic development, bone mass maintenance and tumor progression. As research has advanced, the functional mechanisms of the A‑Raf gene have attracted increasing attention. To systematically summarize its biological functions, the present review focuses on the effects of A‑Raf on the cell cycle, apoptosis and cell proliferation, its influence on cellular material transport and metabolic processes, its role in organismal development and bone mass maintenance, its impact on tumor progression, the effects of genetic variations on A‑Raf function and the regulation of A‑Raf by upstream factors. The present review therefore aimed to provide a novel perspective for the comprehensive understanding of the function of A‑Raf.

Indexed as

Proto-Oncogene Proteins A-rafAnimalsApoptosisCell CycleCell ProliferationHumansNeoplasmsProto-Oncogene Proteins A-rafA‑Rafbiological functionscellular metabolismgenetic variationregulatory mechanism

Identifiers

PMID42429158
PMCPMC13376584

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.