Evidence map›Paper›PMID 42429144›Full record

ReviewMolecular medicine reports2026

Gut dysbiosis‑derived butyrate loss predicts feeding intolerance: Multiomics evidence guiding nurse‑driven microbiota‑supportive interventions (Review).

Ling Wei, Xiaohua Kong, Yuying Li, Huixia Wu, Yirong Gan, Fang Sun

Abstract readReview
In one paragraph

Review in Molecular medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ling WeiNursing Department, Lanzhou First People's Hospital, Lanzhou, Gansu 730000, P.R. China.
Xiaohua KongDepartment of Critical Care Medicine, Lanzhou First People's Hospital, Lanzhou, Gansu 730000, P.R. China.
Yuying LiDepartment of Neonatology, Lanzhou First People's Hospital, Lanzhou, Gansu 730000, P.R. China.
Huixia WuNursing Department, Lanzhou First People's Hospital, Lanzhou, Gansu 730000, P.R. China.
Yirong GanCardiovascular Disease Research Institute, Lanzhou First People's Hospital, Lanzhou, Gansu 730000, P.R. China.
Fang SunDepartment of Obstetrics and Gynecology, Lanzhou First People's Hospital, Lanzhou, Gansu 730000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Feeding intolerance (FI) is a common and debilitating challenge among critically ill patients that is linked to a pathway involving the collapse of the gut microbial ecology. The present review synthesizes multiomics evidence supporting a framework whereby critical illness‑associated gut dysbiosis results in a functional deficit of a microbially derived short‑chain fatty acid butyrate, a pivotal metabolite involved in maintaining intestinal barrier integrity, immuneoregulation and gastrointestinal motility. The loss of butyrate‑producing bacteria and their genetic pathways is strongly correlated with FI and may represent a contributory pathogenic mechanism. Key butyrate‑producing organisms diminished during this process include

Indexed as

ButyratesDysbiosisGastrointestinal MicrobiomeCritical IllnessHumansMultiomicsButyratesbutyratecritical care nursingdysbiosisfeeding intolerancegut microbiotaintensive care unitmicrobiota‑supportive interventionsmulti‑omics

Identifiers

PMID42429144
PMCPMC13376585

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.