Construction of a Glutathione-Gated Intelligent Nanoclassifier for Spatioselective Visualization of Dual CircRNAs and Synergistic Photodynamic Therapy.

Qian Liu, Wenliang Ma, Li-Juan Wang, Chun-Yang Zhang

Abstract read

In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qian LiuSchool of Chemistry and Chemical Engineering, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China.

Wenliang MaDepartment of Thoracic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Li-Juan WangSchool of Chemistry and Chemical Engineering, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China.

Chun-Yang ZhangSchool of Chemistry and Chemical Engineering, State Key Laboratory of Digital Medical Engineering, Southeast University, Nanjing, China.

Funding

Frontier Technologies R&D Program of Jiangsu BF2024063National Natural Science Foundation of China 22474019

6 · The paper itself

Abstract

Circular RNAs (circRNAs) are key endogenous regulators of tumorigenesis and progression, and their high interspecies diversity and strong sequence homology pose a great challenge for simultaneous, live-cell differentiation of multiple circRNA variants. Herein, we construct an intelligent nanoclassifier (DB-CHA@PAN) by assembling disulfide bond (DB)-modified catalytic hairpin assembly (CHA) probes onto programmable cruciform framework-based nanoparticles (PAN) for spatioselective visualization of dual circRNAs and synergistic photodynamic therapy. Upon entering cancer cells, GSH cleaves disulfide bonds to initiate multiple rounds of circRNAs-fueled cyclic CHA cascades, inducing spatial separation of photosensitizer (PS)/BHQ3 and Cy3/BHQ2 pairs and consequently recovery of PS photodynamic activity and Cy3 fluorescence signal. Released PS can generate abundant singlet oxygen (

Indexed as

GlutathioneNanoparticlesPhotochemotherapyPhotosensitizing AgentsRNA, CircularAnimalsFemaleHumansMiceGlutathionePhotosensitizing AgentsRNA, Circularcancer diagnosis and stagingcircular RNAintelligent nanoclassifierphotodynamic therapyspatioselective visualization

Identifiers

PMID42429128

DOI10.1002/anie.6302768

PMCPMC13573129

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.