Evidence map›Paper›PMID 42428893›Full record

ArticleACS omega2026

Synthesis and Investigation of a Novel Platinum(II) Complex Targeting Biotin Receptor-Positive Tumors: In Vitro Evaluation in Cisplatin-Sensitive and -Resistant Cells, Mass Cytometry Profiling, Pharmacokinetics, In Vivo Efficacy, and SMVT-Mediated Uptake.

Natalia Kamperi, Nikolaos Saxonis, Eleni Skavatsou, Athina Mitkani, Maria Goulielmaki, Pelagia Melissa, Vasilis Zoumpourlis, Walter H Moos, Robert J Zamboni, Apostolos Klinakis and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Natalia KamperiCenter for Clinical, Experimental Surgery and Translational Research, Pharmacology-Pharmacotechnology, Biomedical Research Foundation, Academy of Athens, 4 Soranou Ephessiou Street, Athens 11527, Greece.
Nikolaos SaxonisCenter for Clinical, Experimental Surgery and Translational Research, Pharmacology-Pharmacotechnology, Biomedical Research Foundation, Academy of Athens, 4 Soranou Ephessiou Street, Athens 11527, Greece.
Eleni SkavatsouCenter for Clinical, Experimental Surgery and Translational Research, Pharmacology-Pharmacotechnology, Biomedical Research Foundation, Academy of Athens, 4 Soranou Ephessiou Street, Athens 11527, Greece.
Athina MitkaniCenter for Clinical, Experimental Surgery and Translational Research, Pharmacology-Pharmacotechnology, Biomedical Research Foundation, Academy of Athens, 4 Soranou Ephessiou Street, Athens 11527, Greece.
Maria GoulielmakiInstitute of Biology, Medical Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vass Konstantinou Avenue, Athens 11635, Greece.
Pelagia MelissaCenter for Basic Research, Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou Street, Athens 11527, Greece.
Vasilis ZoumpourlisInstitute of Biology, Medical Chemistry and Biotechnology, National Hellenic Research Foundation, 48 Vass Konstantinou Avenue, Athens 11635, Greece.
Walter H MoosDepartment of Pharmaceutical Chemistry, School of Pharmacy, University of California San Francisco, 490 Illinois Street, San Francisco, California 94143, United States.
Robert J ZamboniDepartment of Chemistry, McGill University, 801 Sherbrooke Street, Montreal, Quebec H3A 0G4, Canada.
Apostolos KlinakisCenter for Basic Research, Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou Street, Athens 11527, Greece.
Kosta SteliouCancer Research Center, Boston University School of Medicine, 72 East Concord Street, Boston, Massachusetts 02118, United States.
Nikolaos PaschalidisMass Cytometry-CyTOF Laboratory, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 4 Soranou Ephessiou Street, Athens 11527, Greece.
Constantin TamvakopoulosCenter for Clinical, Experimental Surgery and Translational Research, Pharmacology-Pharmacotechnology, Biomedical Research Foundation, Academy of Athens, 4 Soranou Ephessiou Street, Athens 11527, Greece.ORCID https://orcid.org/0000-0001-9627-4812

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study presents the synthesis and biological evaluation of two DAPA-conjugated platinum-(II) complexes, PMX114 and PMX118, designed as structural analogues of cisplatin and carboplatin. Comparative cytotoxicity assays in cisplatin-sensitive and cisplatin-resistant A2780 ovarian cancer cells showed that PMX114 maintained activity in the resistant cell line, with a resistance index close to unity, although its absolute IC

Identifiers

PMID42428893
PMCPMC13347638

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.