ArticleACS omega2026
A FRET-Based Assay for Assessing Covalent Warhead Reactivity.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Covalent modalities have become increasingly important in drug discovery, yet reliable methods for evaluating the intrinsic reactivity of electrophilic warheads toward different nucleophiles remain a challenge. While Förster resonance energy transfer (FRET)-based fluorescent sensors are widely exploited in chemical biology for the detection of diverse analytes, their potential for probing covalent warhead reactivity has not been explored. Herein, we report the design and application of a FRET-based fluorescent platform for assessing covalent warhead reactivity toward biological nucleophiles. The system incorporates a sulfone-based nucleophilic aromatic substitution (S
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Registered trials
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