ArticleACS omega2026
Development of a Sustainable Analytical Method Using High-Performance Liquid Chromatography (HPLC) and Dissolution Studies for Quality Control of Ibuprofen Soft Gelatin Capsules from Brazil.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Ibuprofen is one of the first anti-inflammatory drugs, and it has recently been developed in soft gelatin capsule form. Therefore, it is the only oral pharmaceutical for which there is no defined quality control method by pharmacopoeias. This study aims to develop an innovative and sustainable HPLC-DAD method for the determination of ibuprofen in soft gelatin capsules and to compare dissolution profiles and kinetics. The optimal conditions for the chromatographic method were a mobile phase (isocratic) consisting of 70% ethanol and 30% of 0.5% acetic acid at a flow rate of 0.8 mL min
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