Evidence map›Paper›PMID 42428866›Full record

ArticleACS omega2026

Antimicrobial Peptides Based on the TisB Toxin: Toward Enhanced Activity and Synergy with Antibiotics.

Emma Dyhr, Ingvill Pedersen Sæbø, Ida Mathilde Marstein Riisnæs, Magnar Bjørås, Emily Helgesen, James Alexander Booth, Henrik Franzyk

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emma DyhrDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, Copenhagen 2100, Denmark.ORCID https://orcid.org/0009-0008-1806-0761
Ingvill Pedersen SæbøDepartment of Microbiology, Oslo University Hospital and the University of Oslo, Rikshospitalet, Oslo 0373, Norway.
Ida Mathilde Marstein RiisnæsDepartment of Microbiology, Oslo University Hospital and the University of Oslo, Rikshospitalet, Oslo 0373, Norway.
Magnar BjøråsDepartment of Microbiology, Oslo University Hospital and the University of Oslo, Rikshospitalet, Oslo 0373, Norway.
Emily HelgesenDepartment of Microbiology, Oslo University Hospital and the University of Oslo, Rikshospitalet, Oslo 0373, Norway.
James Alexander BoothDepartment of Microbiology, Oslo University Hospital and the University of Oslo, Rikshospitalet, Oslo 0373, Norway.
Henrik FranzykDepartment of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, Copenhagen 2100, Denmark.ORCID https://orcid.org/0000-0002-2822-1927

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial resistance is a growing global health crisis, necessitating novel anti-infective agents. The present study explores the potential of toxin-antitoxin (TA) systems as a source of antibiotic candidates. Thus, 44 antimicrobial peptides derived from the TisB type-I TA system were employed to establish initial structure-activity relationships via sequence truncation, cationic modifications, and incorporation of ultrashort PEG-like flexible linkers as well as Ala scanning and partial or full incorporation of D-amino acids. This led to the identification of several hits with promising antibacterial activity (MICs in the range 2-16 μM) against the Gram-negative

Identifiers

PMID42428866
PMCPMC13347394

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.