ArticleACS omega2026
Enhanced Sensitivity in Neurotoxicity Detection via Cross-Correlation of Spectroscopical and Electrophysiological Features.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
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Abstract
Neurotoxicity detection using electrophysiological readouts is limited in sensing chemically induced variations across neuronal ion channels. Thus, supportive knowledge of the neuronal biochemical environment may unveil hidden neurotoxicity mechanisms. Herein, we integrated a spectroscopical, via Raman spectroscopy, and an electrophysiological, via microelectrode array, readout for monitoring the neurotoxic effects of gabazine, a known epileptiform inducer, toward neuronal rat primary cells. The monitoring and correlation of the spectroscopic and electrophysiological features, prior to and following the gabazine exposure, highlighted the advantages in the monitoring and correlation of these biological complementary features, suggesting an innovative and more sensitive approach for neurotoxicity detection in the drug discovery and development pipeline.
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Registered trials
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