ArticleFrontiers in neurology
Distinct medication-state modulation of motor-cortical low-beta power in tremor-dominant and postural instability/gait difficulty Parkinson's disease: a source-space resting-state EEG study.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Source-space electroencephalography (EEG) provides a noninvasive approach for probing oscillatory activity in motor-cortical and cerebellar networks in Parkinson's disease (PD). However, electrophysiological evidence differentiating tremor-dominant (TD) and postural instability/gait difficulty (PIGD) subtypes under a harmonized medication OFF/ON protocol remains limited. We therefore examined whether TD and PIGD differ in medication-state modulation of motor-cortical low-beta power and cerebellum-related connectivity using 64-channel resting-state source-space EEG. Methods: We prospectively enrolled 12 healthy controls, 20 patients with PIGD, and 18 with TD. In a fixed OFF-to-ON sequence, participants underwent 64-channel eyes-closed resting-state EEG. Source-space power spectral density (PSD) and weighted phase lag index (wPLI) were computed for prespecified motor-cortical and cerebellar regions of interest. Primary effects were tested with linear mixed-effects models. Exploratory edge-wise analyses were controlled using the Benjamini-Hochberg false discovery rate (BH-FDR), and network-level effects were assessed with network-based statistics (NBS). Results: For the prespecified primary PSD endpoint, low-beta relative PSD in the primary motor cortex (M1) showed a significant group × state interaction (χ Conclusion: Tremor-dominant and PIGD showed distinct medication-state modulation of motor-cortical low-beta power, with M1 low-beta relative PSD emerging as the most consistent electrophysiological difference in this cohort. By contrast, cerebellum-related connectivity findings were limited to exploratory edge-wise effects and require independent replication.
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