ArticleHealth science reports2026
The Role of Natural Killer (NK) Cells in Dengue Virus Infection: A Narrative Review.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: In the innate immune response, natural Killer (NK) cells have a significant role in protection against viral infections, including the Dengue virus (DENV). NK cells identify and eliminate virus-infected cells through diverse mechanisms, such as cytokine production, cytolytic activity, and antibody-dependent cellular cytotoxicity (ADCC), thereby contributing to reducing viremia and regulating adaptive immunity in the context of DENV. This review summarises the biological mechanisms of NK-cell-mediated immune response against DENV, describes the viral evasion of NK immune protection and explores the insights for the immunotherapeutic approaches and drug development. Methods: To conduct this narrative review, we searched the literature on NK cell activation, receptor expression, cytokine responses, virus evasion strategies, and experimental or emerging therapeutic approaches in DENV. Results: NK cells recognise DENV through the interaction of inhibitory receptors along with the human leukocyte antigen (HLA) class I molecules, which in turn strengthens the ADCC response. DENV can apply virus evasion strategies for modulating NK cell-mediated immunity and reducing the antiviral effect. In addition, impaired and exhausted NK cell phenotypes are associated with the progression and severity of dengue syndromes. Conclusion: NK cells play a double-edged sword in protective response and immune function during DENV. A deeper understanding of their NK cell mechanism, subset heterogeneity, functional response, and evasion strategies governs key insights for vaccines and therapeutic strategies that prompt antiviral immune response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.