ArticleAging medicine (Milton (N.S.W))2026
The Effect of Resistance Training and Ursolic Acid on the PI3K-AKT-mTOR Pathway in Aged Diabetic Rats: A Comparative Study.
Article in Aging medicine (Milton (N.S.W)), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Sarcopenia, characterized by age-related muscle loss, worsens in diabetes due to anabolic resistance. Ursolic acid (UA), a natural compound with anabolic and anti-catabolic effects, may mitigate sarcopenia by enhancing anabolic pathways. This study examined the effects of 8 weeks of resistance training and UA supplementation on PI3K-AKT-mTORC1 pathway proteins in muscle tissue of aged diabetic rats. Methods: Fifty 21-month-old Wistar rats were divided into five groups: healthy control, diabetic control, diabetic + resistance training, diabetic + UA, and diabetic + resistance training + UA. Type 2 diabetes was induced using a high-fat diet and low-dose STZ. Resistance training consisted of 8 weeks of ladder climbing at 60% MVCC, 5 days per week. UA was administered daily to the UA and combination groups. Protein expression was analyzed using Western blot. Results: AKT and mTORC1 or phosphorylated AKT levels did not differ significantly across groups. However, dephosphorylated PI3K ( Conclusion: Diabetes reduces PI3K and mTORC1 protein expression. Resistance training or UA alone improved mTORC1 expression, while their combination enhanced both PI3K and mTORC1, suggesting synergistic anabolic benefits. Combining UA with resistance training may counteract diabetes-induced muscle loss.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.