ReviewFrontiers in pharmacology2026
Natural defense against colorectal cancer: the effects of kaempferol on epigenetics, apoptosis, inflammation, oxidative stress, and cell proliferation.
Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide, driven by complex genetic, epigenetic, and environmental factors. Among natural bioactive compounds, kaempferol (a dietary flavonoid found abundantly in fruits, vegetables, and medicinal plants) has garnered significant attention for its promising anticancer properties. Accumulating evidence suggests that kaempferol exerts multifaceted effects on CRC through modulation of key molecular signaling pathways. These pathways regulate critical cellular processes such as proliferation, invasion, inflammation, angiogenesis, oxidative stress, and apoptosis. Moreover, kaempferol has shown the ability to reverse drug resistance, modulate epigenetic mechanisms, and enhance the efficacy of conventional chemotherapeutics, positioning it as a potential adjuvant therapy in CRC treatment. This review provides an updated overview of the molecular mechanisms underlying the anticancer effects of kaempferol in CRC and highlights the current challenges in translating these findings into clinical applications.
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