Evidence map›Paper›PMID 42428469›Full record

ArticleDystonia (Lausanne, Switzerland)2025

Is thalamic deep brain stimulation the right target to improve laryngeal dystonia symptoms?

Lena C O'Flynn, Michael T Barbe, Shiro Horisawa, Julie M Barkmeier-Kraemer, Andrew Blitzer, Jeremy D W Greenlee, Farid Hamzei-Sichani, Paolo Moretti, Srikantan S Nagarajan, Nutan Sharma and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dystonia (Lausanne, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lena C O'FlynnDepartment of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, United States.
Michael T BarbeUniversity Hospital Cologne, Department of Neurology, Cologne, Germany.
Shiro HorisawaDepartment of Neurosurgery, Tokyo Women's Medical University, Tokyo, Japan.
Julie M Barkmeier-KraemerDepartment of Communication Sciences and Disorders, The University of Utah, Salt Lake City, UT, United States.
Andrew BlitzerDepartment of Otolaryngology-Head and Neck Surgery, Columbia University College of Physicians and Surgeons, New York, NY, United States.
Jeremy D W GreenleeDepartment of Neurosurgery, University of Iowa, Iowa City, IA, United States.
Farid Hamzei-SichaniDepartment of Neurological Surgery, University of Massachusetts Medical School, UMass Memorial Healthcare, Worcester, MA, United States.
Paolo MorettiDepartment of Neurology, The University of Utah, Salt Lake City, UT, United States.
Srikantan S NagarajanDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States.
Nutan SharmaDepartment of Neurology, Massachusetts General Hospital, Boston, MA, United States.
Shervin RahimpourDepartment of Neurosurgery, The University of Utah, Salt Lake City, UT, United States.
Jan RuszDepartment of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czechia.
Elina TripolitiDepartment of Clinical and Movement Neurosciences, Institute of Neurology, University College London, National Hospital for Neurology and Neurosurgery, UCLH NHS Trust, London, United Kingdom.
Giovanni BattistellaDepartment of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, United States.
Kristina SimonyanDepartment of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA, United States.

Funding

Understanding disorder-specific neural pathophysiology in laryngeal dystonia and voice tremorP50DC019900 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Kristina Simonyan · 2021 to 2026
$11.9M
Imaging genetics of spasmodic dysphoniaR01DC011805 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Kristina Simonyan · 2012 to 2026
$8.8M
Voice tremor in spasmodic dysphonia: central mechanisms and treatment responseR01DC012545 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI SIMONYAN, KRISTINA · 2012 to 2021
$5.2M
The role of the cerebellum in speechR01DC017091 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John Francis Houde, RICHARD IVRY · 2019 to 2026
$4.5M
Physiologic Correlates of Vocal Tremor affecting those with Essential TremorR01DC016838 · NIDCD · UNIVERSITY OF UTAH · PI BARKMEIER-KRAEMER, JULIE M · 2019 to 2023
$3.0M
Genetic Variants in Craniofacial DystoniasR01DE030464 · NIDCR · MASSACHUSETTS GENERAL HOSPITAL · PI NUTAN SHARMA · 2022 to 2026
$3.0M
Clinical Validation of DystoniaNet Deep Learning Platform for Diagnosis of Isolated DystoniaR01NS124228 · NINDS · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Kristina Simonyan · 2022 to 2026
$2.7M
Electrophysiological and molecular imaging of early AD progressionR01AG088398 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kamalini Gayathree Ranasinghe · 2024 to 2026
$2.4M
Dynamic Brain Imaging of Speech in Primary Progressive AphasiaRF1NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA, HOUDE, JOHN FRANCIS · 2023 to 2023
$2.4M
Brain Networks in DystoniaR01NS088160 · NINDS · MASSACHUSETTS EYE AND EAR INFIRMARY · PI SIMONYAN, KRISTINA · 2015 to 2019
$2.4M
Adaptive closed-loop brain-computer interface therapeutic intervention in laryngeal dystoniaR01DC019353 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI SIMONYAN, KRISTINA · 2021 to 2025
$1.8M
Phenotyping the neural basis of sensorimotor control of speech in 16p11.2 deletion syndromeR01DC021711 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Carly Demopoulos, John Francis Houde · 2025 to 2026
$1.4M
NIA NIH HHS R01 AG088398NIDCD NIH HHS P50 DC019900NIDCD NIH HHS R01 DC011805NIDCD NIH HHS R01 DC012545NIDCD NIH HHS R01 DC016838NIDCD NIH HHS R01 DC017091NIDCD NIH HHS R01 DC019353NIDCD NIH HHS R01 DC021711NIDCD NIH HHS R21 DC021557NIDCR NIH HHS R01 DE030464NINDS NIH HHS R01 NS088160NINDS NIH HHS R01 NS124228NINDS NIH HHS RF1 NS100440
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

clinical trialdeep brain stimulationlaryngeal dystonianeuromodulationvoice tremor

Identifiers

PMID42428469
PMCPMC13348808

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.