ArticleJournal of orthopaedic case reports2026
Diagnostic Dilemma in a Distal Femoral Intramedullary Lesion: Enchondroma Mimicking Low-Grade Chondrosarcoma with Discordant Biopsy Findings: A Case Report.
Article in Journal of orthopaedic case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Differentiating enchondroma from low-grade chondrosarcoma remains challenging due to significant overlap in clinical presentation, imaging characteristics, and histopathological appearance. Accurate diagnosis is crucial in guiding appropriate treatment and preventing unnecessary aggressive management. Case Report: A 25-year-old female presented with progressive right knee pain for 20 days. Te X-ray was inconclusive. Magnetic resonance imaging demonstrated a well-defined intramedullary lesion within the distal femur measuring approximately 7.6 × 2.6 × 3 cm. Initial computed tomography (CT)-guided biopsy results were inconclusive. Repeat imaging, including magnetic resonance imaging and positron emission tomography-CT, suggested a non-aggressive lesion without metastatic disease. After multidisciplinary tumor board discussion, a repeat biopsy demonstrated a cartilaginous neoplasm compatible with enchondroma. The patient subsequently underwent intralesional curettage with antibiotic-loaded bone cement filling. Final histopathological analysis confirmed a benign enchondroma. Conclusion: This report highlights the importance of clinicoradiological correlation and repeat biopsy when initial investigations provide conflicting information in suspected cartilage tumors.
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