ArticleJournal of orthopaedic case reports2026
Angiofibroma of Knee Masquerading as Ganglion Cyst - A Rare Case Report.
Article in Journal of orthopaedic case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Angiofibroma of soft tissue (AFST) is a rare benign neoplasm characterized by distinctive histopathological and genetic features. It commonly arises in the lower extremities but can present in atypical locations, complicating diagnosis. Case Report: A 77-year-old male with a 10-year history of bilateral knee pain and 6-month history of right knee swelling was examined. Physical assessment revealed bilateral knee varus deformity and a palpable, variable-consistency mass in the anteromedial aspect of the right knee. Radiographs indicated severe osteoarthritis and soft-tissue swelling. Magnetic resonance imaging showed cystic collections consistent with a ganglion cyst. Surgical excision exposed a superficial cystic mass and a deeper firm mass, confirmed histopathologically as a ganglion cyst and AFST, respectively. Immunohistochemical tests were negative for epithelial membrane antigen, S-100, and Vimentin. The patient is under regular follow-up with no recurrence in the last 12 months. Conclusion: AFST should be included in the differential diagnosis of soft-tissue masses. Comprehensive diagnostic evaluations, including detailed imaging and histopathological analysis, are crucial for accurate diagnosis. Surgical excision is effective, with a favorable prognosis and low recurrence risk.
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