Evidence map›Paper›PMID 42428307›Full record

ArticleFrontiers in microbiology2026

Clinical characteristics and associated factors of cholestasis in infant's ≤3 months with cytomegalovirus infection.

Wenmei Li, Kun Wang, Haifeng Geng, Xinjing Lv, Caimei Li, Qinghui Chen, Fangfang Cheng, Weifang Zhou, Jianmei Tian, Huawei Wang and 1 more

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Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Wenmei LiDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Kun WangDepartment of Infectious Diseases, Children's Hospital of Soochow University, Suzhou, China.
Haifeng GengDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Xinjing LvDepartment of Infectious Diseases, Children's Hospital of Soochow University, Suzhou, China.
Caimei LiDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Qinghui ChenDepartment of Infectious Diseases, Children's Hospital of Soochow University, Suzhou, China.
Fangfang ChengDepartment of Infectious Diseases, Children's Hospital of Soochow University, Suzhou, China.
Weifang ZhouDepartment of Infectious Diseases, Children's Hospital of Soochow University, Suzhou, China.
Jianmei TianDepartment of Infectious Diseases, Children's Hospital of Soochow University, Suzhou, China.
Huawei WangDepartment of Neonatology, Children's Hospital of Soochow University, Suzhou, China.
Lin CheDepartment of Infectious Diseases, Children's Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The clinical characteristics and contributing factors of cholestasis in infants with cytomegalovirus (CMV) infection remain incompletely understood. This study aimed to investigate the clinical features and associated factors of cholestasis in infants with CMV infection. Methods: This retrospective case-control study enrolled infants aged ≤3 months with confirmed CMV infection. Infants with cholestasis were classified as cases, and age-matched infants without cholestasis were randomly selected as controls in a 1:1 ratio. Clinical and laboratory characteristics were compared between groups. Factors independently associated with cholestasis were identified using multivariable logistic regression analysis, and a predictive nomogram was constructed accordingly. Furthermore, an exploratory phenotype axis framework was applied to delineate the multidimensional clinical characteristics of CMV-infected infants. Results: A total of 64 infants with CMV infection and cholestasis were included. Compared with controls, infants with cholestasis had a later onset and longer duration of jaundice, a lower rate of passing hearing screening, and longer hospital stays (all Conclusion: In infants with CMV infection, delayed onset of jaundice was independently associated with cholestasis, whereas higher total protein levels, higher CD4

Indexed as

cholestasiscytomegalovirusimmune profileinfantliver function

Identifiers

PMID42428307
PMCPMC13346084

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