Evidence map›Paper›PMID 42428277›Full record

ArticleFrontiers in medicine2026

Construction and validation of a risk prediction model for early ventilator-induced diaphragm dysfunction in mechanically ventilated patients.

Min-Qing Long, Yu-Ting Liu

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Min-Qing LongDepartment of Critical Care Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital/Shenzhen Nanshan People's Hospital, Shenzhen, Guangdong, China.
Yu-Ting LiuDepartment of Critical Care Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital/Shenzhen Nanshan People's Hospital, Shenzhen, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mechanical ventilation is a core life-support technique in intensive care units (ICUs), but it can easily induce ventilator-induced diaphragm dysfunction (VIDD) in the early stage of mechanical ventilation (within 24 h). VIDD is defined as new-onset diaphragm dysfunction caused by mechanical ventilation, and diaphragm ultrasound is the gold standard for its diagnosis. This study aimed to explore the risk factors of early VIDD in mechanically ventilated patients and construct a temporally validated risk prediction model using clinical baseline indicators. Methods: A prospective study was conducted on 470 mechanically ventilated patients who were admitted to the ICU of Shenzhen Nanshan People's Hospital from May 2024 to May 2025. Patients were divided into a modeling group ( Results: Among 328 patients in the modeling group, 160 developed VIDD, with an incidence rate of 48.78%. Independent risk factors for VIDD included complicated sepsis, controlled mechanical ventilation mode, Richmond agitation-sedation scale (RASS) score ≤ - 4, acute physiology and chronic health evaluation II (APACHE II) score >20, and complicated intra-abdominal hypertension (IAP ≥ 16 mmHg) (all Conclusion: The nomogram model constructed based on the five risk factors exhibited favorable efficacy for predicting early VIDD. Therefore, the model can be applied as a convenient quantitative tool for the early identification of high-risk patients in clinical practice.

Indexed as

mechanical ventilationnomogramtemporal validationultra-early risk predictionventilator-induced diaphragm dysfunction

Identifiers

PMID42428277
PMCPMC13346164

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