Evidence map›Paper›PMID 42428256›Full record

SynthesisEnvironmental health perspectives2026

Prenatal Smoking Exposures and Epigenome-Wide Methylation in Newborn Blood.

Thanh T Hoang, Marta Cosin-Tomas, Yunsung Lee, Giulietta Monasso, Zongli Xu, Sebastian Shaobo Li, Xuehuo Zeng, Anne P Starling, Brigitte Reimann, Stefan Röder and 46 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Environmental health perspectives, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Smoking drives an epigenetic memory of aberrant hematopoiesis.medRxiv : the preprint server for health sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

56 authors.

Thanh T HoangDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, United States.
Marta Cosin-TomasISGlobal, Barcelona Institute for Global Health, 08036 Barcelona, Spain.
Yunsung LeeCentre for Fertility and Health, Norwegian Institute of Public Health, 0213 Oslo, Norway.
Giulietta MonassoThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
Zongli XuBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, United States.
Sebastian Shaobo LiCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California 90089, United States.
Xuehuo ZengGlotech, Inc., Rockville, Maryland 20850, United States.
Anne P StarlingLifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States.
Brigitte ReimannCentre for Environmental Sciences (CMK), Hasselt University, 3590 Diepenbeek, Belgium.ORCID 0000-0003-3634-4633
Stefan RöderDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research - UFZ, 04318 Leipzig, Germany.
Lea ZillichDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68135 Mannheim, Germany.
Dereje D JimaCenter for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina 27695, United States.
Chris H L ThioDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Giancarlo PesceEpidemiology of Allergic and Respiratory Diseases (EPAR) Team, Faculté de Médecine Saint-Antoine, Institute Pierre Louis d'Epidemiologie et Sante Publique (IPLESP), Sorbonne Université and INSERM UMR-S 1136, Paris, France.
Elin T G KerstenUniversity Medical Center Groningen, University of Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, 9713 GZ Groningen, The Netherlands.
Charles E BreezeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, United States.
Adam B BurkholderOffice of Environmental Science Cyberinfrastructure, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, United States.
Mikyeong LeeDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, United States.
James M WardIntegrative Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, United States.ORCID 0000-0002-9510-2848
BIOS Consortium
Rossella AlfanoCentre for Environmental Sciences (CMK), Hasselt University, 3590 Diepenbeek, Belgium.
Michael DeuschleDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68135 Mannheim, Germany.
Liesbeth DuijtsDepartment of Pediatrics, Division of Respiratory Medicine and Allergology a Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Akhgar GhassabianDepartment of Pediatrics, New York University Grossman School of Medicine, New York, New York 10016, United States.ORCID 0000-0001-9551-4706
Laura-Concepció Gómez HerreraISGlobal, Barcelona Institute for Global Health, 08036 Barcelona, Spain.
Vincent Wv JaddoeThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
Alison A Motsinger-ReifBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, United States.
Rolv T LieCentre for Fertility and Health, Norwegian Institute of Public Health, 0213 Oslo, Norway.
Tim S NawrotCentre for Environmental Sciences, Hasselt University, 3500 Hasselt, Belgium.
Christian M PageDepartment of Physical Health and Ageing, Division of Public Health and Prevention, Norwegian Institute of Public Health, 0213 Oslo, Norway.
Tabea S SendDepartment of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68135 Mannheim, Germany.
Gemma SharpSchool of Psychology, University of Exeter, Exeter EX4 4QG, United Kingdom.
Dan J SteinDepartment of Psychiatry, Neuroscience Institute, Faculty of Health Sciences, University of Cape Town, Cape Town 7701, South Africa.
Fabian StreitDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68135 Mannheim, Germany.
Jordi SunyerISGlobal, Barcelona Institute for Global Health, 08036 Barcelona, Spain.
Allen J WilcoxEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, United States.
Heather J ZarDepartment of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital and South African Medical Research Council (SAMRC) Unit on Child and Adolescent Health, Cape Town 7700, South Africa.
Gerard H KoppelmanUniversity Medical Center Groningen, University of Groningen, Beatrix Children's Hospital, Department of Pediatric Pulmonology and Pediatric Allergology, 9713 GZ Groningen, The Netherlands.
Isabella Annesi-MaesanoInstitute Desbrest of Epidemiology and Public Health UMR1318, INSERM et Université de Montpellier, Montpellier 34295, France.
Eva CorpeleijnDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands.
Cathrine HoyoCenter for Human Health and the Environment, North Carolina State University, Raleigh, North Carolina 27695, United States.
Anke HülsDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, United States.ORCID 0000-0002-6005-417X
Lea SirignanoDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68135 Mannheim, Germany.
Stephanie H WittDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68135 Mannheim, Germany.
Gunda HerberthDepartment of Environmental Immunology, Helmholtz Centre for Environmental Research - UFZ, 04318 Leipzig, Germany.
Michelle PlusquinCentre for Environmental Sciences (CMK), Hasselt University, 3590 Diepenbeek, Belgium.ORCID 0000-0002-7271-9722
Dana DabeleaLifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, United States.
Edwina YeungEpidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland 20892, United States.
Joseph L WiemelsCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California 90089, United States.
Rebecca C RichmondMRC Integrative Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, United Kingdom.
Jack A TaylorHector Institute for Artificial Intelligence in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68135 Mannheim, Germany.
Janine F FelixThe Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.
Siri E HåbergCentre for Fertility and Health, Norwegian Institute of Public Health, 0213 Oslo, Norway.
Mariona BustamanteISGlobal, Barcelona Institute for Global Health, 08036 Barcelona, Spain.
Stephanie J LondonDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, United States.

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
GENETIC AND ENVIRONMENTAL FACTORS IN CHILDHOOD RESPIRATORY HEALTHZ01ES049019 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE JOAN · 1996 to 2008
$537k
Intramural NIH HHS Z01 ES049019NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

backgroundMaternal sustained smoking during pregnancy is associated with thousands of differentially methylated CpGs in newborns, but impacts of other prenatal tobacco smoking exposures remain unclear.

objectiveTo identify differential DNA methylation in newborns from maternal sustained smoking and less studied prenatal smoking exposures (i.e., maternal exposure to secondhand smoke [SHS] exposure during pregnancy, maternal quitting before pregnancy, paternal smoking around conception, and paternal quitting before pregnancy).

methodsWe conducted a large meta-analysis of prenatal tobacco smoking exposures and epigenome-wide newborn blood DNA methylation through the Pregnancy And Childhood Epigenetics Consortium (PACE). Across 19 cohorts, 11,175 parent-newborn pairs contributed information on at least one prenatal smoking exposure, mostly from questionnaires. Maternal blood or urine cotinine measurements, available in a few studies, provided objective data for maternal SHS and smoking during pregnancy. Primary analyses used Illumina450 K methylation data; secondary analyses in 5 cohorts examined CpGs unique to the EPIC array.

resultsMaternal sustained smoking associated with differential DNA methylation (false discovery rate [FDR] < 0.05) at 8,862 CpGs on the 450 K (

conclusionsMaternal sustained smoking has the largest impact on newborn DNA methylation, suggesting a strong influence of the intrauterine environment. We observed minimal impacts for less studied exposures including SHS, maternal former smoking, and paternal smoking.

Indexed as

DNA MethylationEpigenomeMaternal ExposurePrenatal Exposure Delayed EffectsSmokingTobacco Smoke PollutionCotinineEpigenesis, GeneticFemaleHumansInfant, NewbornMalePregnancyCotinineTobacco Smoke Pollution

Identifiers

PMID42428256
PMCPMC13347645

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.