ArticleHuman mutation2026
Immune Cell Profiles and Novel Insights Into Cancer Risk: A Focus on Oral and Pharyngeal Cancer.
Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Immune Cell Profiles and Novel Insights Into Cancer Risk: A Focus on Oral and Pharyngeal Cancer.Human mutation · 2026Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objective: Oral and pharyngeal cancers affect 850,000 new cases annually with 440,000 deaths worldwide. This study explores the causal relationship between immune cell profiles and oral-pharyngeal cancer risk through Mendelian randomization analysis integrated with experimental validation. Methods: A two-sample Mendelian randomization study was conducted using the MRC IEU OpenGWAS platform, analyzing data from 3757 European individuals for immune cell profiles and 4671 oral-pharyngeal cancer cases, with 80% statistical power to detect OR ≥ 1.2. Multiple Mendelian randomization methods were employed, including inverse-variance weighted, MR-Egger, and weighted median approaches. Findings were validated through coculture experiments examining immune cell-cancer cell interactions via flow cytometry. Results: Among 731 immune traits analyzed, Mendelian randomization revealed elevated cancer risk associated with CD127 on CD45RA+ CD4+ T cells (OR = 1.33, 95% CI: 1.04-1.70, Conclusion: This integrated analysis not only reveals novel immune cell-cancer risk associations and their underlying mechanisms but also provides promising opportunities for personalized immunotherapy development in oral-pharyngeal cancer. These findings enable precise patient stratification based on immune cell profiles and suggest tailored therapeutic strategies that could significantly improve clinical outcomes.
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