ArticleHuman mutation2026
Genetic Links Between Cancer and Coronary Atherosclerosis: A Mendelian Randomization Analysis.
Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Genetic Links Between Cancer and Coronary Atherosclerosis: A Mendelian Randomization Analysis.Human mutation · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: While observational studies have indicated a potential link between cancer and coronary atherosclerosis, the relationship remains obscured by confounding factors. Elucidating a shared genetic basis may uncover common pathophysiological pathways. Methods: We employed a two-sample Mendelian randomization (MR) approach to evaluate causal relationships between 23 cancer types and coronary atherosclerosis. Reverse MR analysis was also conducted to explore potential bidirectional effects. Given the exploratory nature of this pan-cancer analysis, we report nominal significance ( Results: Forward MR analysis identified nominally significant associations between coronary atherosclerosis and five cancer types; however, after rigorous sensitivity analyses, only the inverse associations with pancreatic cancer (OR = 0.90, 95 Interpretation: This comprehensive large-scale MR study provides hypothesis-generating evidence for a bidirectional genetic interplay between cardiovascular and oncological diseases. These findings point to a complex interplay between these conditions, paving the way for future investigations into shared mechanisms and integrated therapeutic strategies. However, all associations should be interpreted as suggestive rather than definitive causal evidence, and validation in independent cohorts is warranted.
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Registered trials
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