Evidence map›Paper›PMID 42428182›Full record

ArticleCureus2026

Clinical Efficacy Comparison Between Brush-and-Floss and Brush-and-Rinse Daily Oral Hygiene Regimens on Plaque and Gingivitis in a Six-Week Randomized Clinical Model.

Jeffery L Milleman, Reinhard Schuller, Kimberly R Milleman, Gregori M Kurtzman

Abstract read
In one paragraph

Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jeffery L MillemanClinical Research, Salus Research, Fort Wayne, USA.
Reinhard SchullerPharmacology and Therapeutics, University of Toronto, Toronto, CAN.
Kimberly R MillemanClinical Research, Salus Research, Fort Wayne, USA.
Gregori M KurtzmanGeneral Dentistry and Implantology, Private Practice, Silver Spring, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This prospective randomized study, examiner-blind, parallel-group clinical evaluating the comparative efficacy of a brush-and-rinse regimen versus a brush-and-floss regimen on plaque accumulation and gingival inflammation over 42 days. Seventy-six subjects brushed twice daily and were assigned to either daily flossing (control) or daily antimicrobial rinsing (test). Modified Gingival Index (MGI), Bleeding Index (BI), and Plaque Index (PI) were recorded at baseline, Day 14, and Day 42. The brush-and-rinse regimen demonstrated statistically significant reductions in MGI, BI, and PI from baseline (p<0.001). At Day 42, whole-mouth MGI improved 35% and BI 61.9%, while the control group showed minimal or negative change. Between-group analysis confirmed the statistical superiority of adjunctive rinsing for both gingival and plaque endpoints. Within the limitations of this six-week model, antimicrobial rinsing provided superior clinical outcomes compared with daily flossing.

Indexed as

activated chlorine dioxideantimicrobial mouth rinsedental biofilmgingival inflammationgingivitisoral hygieneplaque controltoothbrushing

Identifiers

PMID42428182
PMCPMC13347901

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.