Chitosan coating effects on biological response to niobia-modified yttria-stabilized zirconia.

Le Na Lau, Chae-Ryeong Cha, Satoshi Imazato, In-Sung Luke Yeo

Abstract read

In one paragraph

Article in The journal of advanced prosthodontics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Le Na LauDepartment of Prosthodontics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.ORCID https://orcid.org/0009-0002-3092-6755

Chae-Ryeong ChaDepartment of Prosthodontics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.ORCID https://orcid.org/0009-0009-9228-4269

Satoshi ImazatoDepartment of Dental Biomaterials, Graduate School of Dentistry, The University of Osaka, Suita, Osaka, Japan.ORCID https://orcid.org/0000-0003-3655-4809

In-Sung Luke YeoDepartment of Prosthodontics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea.ORCID https://orcid.org/0000-0002-6780-2601

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe impact of chitosan (Ch) surface modification on the osseointegration of niobia-modified yttria-stabilized zirconia (Y,Nb-TZP) implants was assessed using a rabbit tibia model. MATERIALS AND

methodsY,Nb-TZP and SLA discs and implants were prepared and coated with Ch of 95% degree of deacetylation (DDA). MC3T3-E1 cells and human gingival fibroblasts were cultured onto discs (n = 3) for cell proliferation, adhesion, osteogenic differentiation and gene expression analysis. Specimen surface characteristics were assessed using scanning electron microscopy and confocal laser scanning microscopy. Eight rabbits underwent tibial implant placement and were euthanized at 2 and 8 weeks after surgery (n = 4). Bone-to-implant contact (BIC) and bone area (BA) were quantified through histomorphometric evaluation. One-way ANOVA with Tukey's post hoc test was used for statistical analysis (

resultsCh-coated Y,Nb-TZP discs supported cell attachment, proliferation, and osteogenic differentiation

conclusionAlthough Ch promoted osteogenic activity

Indexed as

ChitosanDental implantsNiobium pentoxideOsseointegrationZirconium oxide

Identifiers

PMID42428164

DOI10.4047/jap.2026.18.3.191

PMCPMC13346847

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