Evidence map›Paper›PMID 42428137›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Nucleus-specific thalamic involvement in seizure networks differentiates neuromodulation outcomes.

Brian Ji, Peter Hadar, Birgit Frauscher, Shruti Agashe, Derek Southwell, Kassem Jaber, Behnaz Esmaeili, Shahin Hakimian, Benjamin L Grannan, R Mark Richardson and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Brian JiCenter for Neurotechnology and Neurorecovery, Boston, MA 02114, USA.
Peter HadarCenter for Neurotechnology and Neurorecovery, Boston, MA 02114, USA.
Birgit FrauscherDepartment of Neurology, Duke University, Durham, NC 27710, USA.
Shruti AgasheDepartment of Neurology, Duke University, Durham, NC 27710, USA.
Derek SouthwellDepartment of Neurosurgery, Duke University, Durham, NC 27710, USA.
Kassem JaberDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Behnaz EsmaeiliDepartment of Neurology, University of Washington, Seattle, WA 98195, USA.
Shahin HakimianDepartment of Neurology, University of Washington, Seattle, WA 98195, USA.
Benjamin L GrannanDepartment of Neurosurgery, University of Washington, Seattle, WA 98195, USA.
R Mark RichardsonDepartment of Neurosurgery, Mass General Brigham, Boston, MA 02114, USA.
Sydney S CashCenter for Neurotechnology and Neurorecovery, Boston, MA 02114, USA.
Pariya SalamiCenter for Neurotechnology and Neurorecovery, Boston, MA 02114, USA.

Funding

256-channel Digital Neural Signal Processor Real-Time Data Acquisition SystemS10OD034414 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S · 2023 to 2023
$554k
NIH HHS S10 OD034414
6 · The paper itself

Abstract

Closed-loop neuromodulation via responsive neurostimulation (RNS) of the thalamus has emerged as a promising therapy for drug-resistant epilepsy (DRE), particularly in patients with broad or multifocal onset. However, response to thalamic RNS is inconsistent, and there is a crucial need to identify factors that distinguish responders from non-responders. Given the heterogeneous composition of the thalamus, the specific contributions of individual thalamic nuclei during seizures may explain the variability in outcomes between patients and could potentially serve as biomarkers for guiding target selection. We analyzed 129 seizures from 28 patients with DRE who underwent stereo-EEG monitoring with recordings of the centromedian (CM:

Indexed as

centromedian nucleusdrug-resistant epilepsyfunctional connectivitypulvinar nucleusresponsive neurostimulationthalamus

Identifiers

PMID42428137
PMCPMC13345580

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.