Evidence map›Paper›PMID 42428080›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Race and Socioeconomic Status Impact Survival from Early and Late-Onset Colorectal Cancer.

Kristen Purrington, Mei-Chin Hsieh, Siddhi Patil, Batsirai Mabvakure, Jaeil Ahn, Rui Zhang, Julie J Ruterbusch, Rashmi Samdani, Grace Lee, Angela Wenzlaff and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Kristen PurringtonSchool of Medicine, Wayne State University, Detroit, MI 48202, USA.
Mei-Chin HsiehEpidemiology and Population Health Program, Louisiana Tumor Registry, School of Public Health, Louisiana State University Health-New Orleans, New Orleans, LA 70112, USA.
Siddhi PatilGeorgetown-Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.
Batsirai MabvakureGeorgetown-Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.
Jaeil AhnDepartment of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University Medical Center, Georgetown University, Washington, DC 20057, USA.
Rui ZhangDepartment of Biostatistics, Bioinformatics, and Biomathematics, Georgetown University Medical Center, Georgetown University, Washington, DC 20057, USA.
Julie J RuterbuschSchool of Medicine, Wayne State University, Detroit, MI 48202, USA.
Rashmi SamdaniDepartment of Pathology, MedStar Georgetown University Hospital, Washington, DC, USA.
Grace LeeGeorgetown-Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.
Angela WenzlaffSchool of Medicine, Wayne State University, Detroit, MI 48202, USA.
Sophia LatifMilken Institute of Public Health, George Washington University, Washington, DC.
Chiranjeev DashGeorgetown-Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.
Maureen SartorDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Ann G SchwartzSchool of Medicine, Wayne State University, Detroit, MI 48202, USA.
Elena M StoffelDivision of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Laura S RozekGeorgetown-Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.

Funding

Aggressive colorectal cancer subtypes and social disadvantage in a racially diverse cohortR01CA259420 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kristen S. Purrington, LAURA ROZEK · 2021 to 2026
$3.4M
NCI NIH HHS R01 CA259420
6 · The paper itself

Abstract

Background: Colorectal cancer (CRC) disproportionately affects non-Hispanic Black (NHB) Americans compared to Non-Hispanic White (NHW), with more cases arising before age 50. Racial disparities in outcomes reflect complex interactions among healthcare access, socioeconomic factors, and structural racism, yet analyses linking individual-level data for these factors to survival remain limited. Methods: We examined overall and CRC-specific survival among NHB and NHW patients diagnosed between 2013 and 2022 enrolled in the Disparities and Cancer Epidemiology (DANCE) cohort, a population-based study of CRC in metropolitan Detroit and Louisiana. Multivariable Cox regression and competing-risks models were used to assess the roles of race, age of onset, neighborhood deprivation, and stage on survival outcomes. Results: Among 1,019 CRC cases (57% NHB, 43% NHW), NHB patients were more likely to reside in high-deprivation neighborhoods, report lower household incomes, and present with right-sided tumors, though stage at diagnosis did not differ by race. In multivariable analysis, stage was the strongest predictor of survival, while neighborhood deprivation (per 10-unit ADI increase: HR = 1.14) was independently associated with worse survival; NHB race was not significantly associated with survival after adjustment. Younger age at diagnosis was associated with a survival advantage in regional-stage disease but paradoxically with worse survival in distant-stage disease, and higher deprivation predicted worse survival in both local and distant but not regional stage. Conclusion: Our study shows that socioeconomic factors, as measured by ADI and household income, accounts for some, but not all, of the disparities in survival between NHB and NHW CRC cases.

Identifiers

PMID42428080
PMCPMC13345500

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.