Evidence map›Paper›PMID 42428073›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Shared trans-ancestry architecture of HLA-mediated disease risk in the

Kwangmi Ahn, John S House, Adam Burkholder, Tam C Tran, Joseph H Breeyear, Cristina M Justice, Jacqueline Durney, Alyssa M Jones, Parker S Reyes, Matthew H Bailey and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Kwangmi AhnBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Division of Intramural Research, Research Triangle Park, NC 27709.
John S HouseBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Division of Intramural Research, Research Triangle Park, NC 27709.
Adam BurkholderOffice of Environmental Science Cyberinfrastructure, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, Research Triangle Park, NC 27709.
Tam C TranPrecision Health Informatics Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
Joseph H BreeyearBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Division of Intramural Research, Research Triangle Park, NC 27709.
Cristina M JusticeBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Division of Intramural Research, Research Triangle Park, NC 27709.
Jacqueline DurneyDepartment of Biology, Brigham Young University, Provo, UT, 84602.
Alyssa M JonesDepartment of Biology, Brigham Young University, Provo, UT, 84602.
Parker S ReyesDepartment of Biology, Brigham Young University, Provo, UT, 84602.
Matthew H BaileyDepartment of Biology, Brigham Young University, Provo, UT, 84602.
Mary F DavisDepartment of Biology, Brigham Young University, Provo, UT, 84602.
Anthony T VicentiDepartment of Pharmacy Practice and Science, R Ken Coit College of Pharmacy, University of Arizona, Tucson, AZ 85721.
Jason H KarnesDepartment of Pharmacy Practice and Science, R Ken Coit College of Pharmacy, University of Arizona, Tucson, AZ 85721.
Jill A HollenbachDepartment of Neurology and Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158.
David C FargoOffice of Environmental Science Cyberinfrastructure, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, Research Triangle Park, NC 27709.
Geoffrey S GinsburgAll of Us Research Program, Office of the Director, National Institutes of Health, Bethesda, MD 20892.
Richard P WoychikOffice of the Director, National Institutes of Health, Bethesda, MD 20892.
Josh C DennyPrecision Health Informatics Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
Alison A Motsinger-ReifBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Division of Intramural Research, Research Triangle Park, NC 27709.

Funding

Genetic predisposition and misdiagnosis of cancer in All of Us participantsR15CA293800 · NCI · BRIGHAM YOUNG UNIVERSITY · PI BAILEY, MATTHEW H · 2024 to 2024
$434k
NCI NIH HHS R15 CA293800
6 · The paper itself

Abstract

The human leukocyte antigen (HLA) region is the strongest genetic contributor to many immune-mediated diseases, yet whether HLA architecture is shared across ancestries remains unclear. We analyzed high-resolution HLA variation in 390,823 participants from the

Identifiers

PMID42428073
PMCPMC13345497

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.