Evidence map›Paper›PMID 42428056›Full record

ArticlemedRxiv : the preprint server for health sciences2026

SOMATIC MUTATION PROFILES IN COLORECTAL CANCERS DIFFER BY POPULATION.

Batsirai M Mabvakure, Patharapa Promprasert, Lucia Martinez Cruz, Siddhi Patil, John Barros, Matthew Hayhurst, Elham Mohebbi, Deborah de la Caridad Delgado Herrera, Grace Lee, Sophia Latif and 15 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Batsirai M MabvakureCancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Patharapa PromprasertCancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Lucia Martinez CruzCancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Siddhi PatilCancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
John BarrosCancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Matthew HayhurstCancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Elham MohebbiCancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Deborah de la Caridad Delgado HerreraCancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Grace LeeCancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Sophia LatifCancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Fiona WilliamsCancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Rashmi SamdaniCancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Anju DuttargiCancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
Bereket BerhaneSt Paul Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Esmael BesufikadSt Paul Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Selamawit TadesseSt Paul Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Aisha Jibril SuleimanSt Paul Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Christina LefanteSchool of Public Health, Epidemiology Program, Louisiana State University Health Sciences Center, New Orleans, LA.
Mei-Chin HsiehSchool of Public Health, Epidemiology Program, Louisiana State University Health Sciences Center, New Orleans, LA.
Kristen PurringtonKarmanos Cancer Institute, Wayne State University School of Medicine, 4100 John R, Mail code: MM04EP, Detroit, MI 48201.
Ernest AdjeiKomfo Anokye Teaching Hospital, Okomfo Anokye Road, Kumasi, Ghana.
Tingting QinDepartment of Computational Medicine and Bioinformatics, University of Michigan.
Maureen SartorDepartment of Computational Medicine and Bioinformatics, University of Michigan.
Elena M StoffelUniversity of Michigan Rogel Cancer Center, Ann Arbor, Michigan.
Laura S RozekCancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.

Funding

Aggressive colorectal cancer subtypes and social disadvantage in a racially diverse cohortR01CA259420 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kristen S. Purrington, LAURA ROZEK · 2021 to 2026
$3.4M
NCI NIH HHS R01 CA259420
6 · The paper itself

Abstract

purposeColorectal cancer (CRC) incidence and mortality rates differ by population, and evidence suggests that genetic differences may affect cancer biology. However, studies investigating CRC variants in genetically heterogeneous populations are limited. Using somatic tumor mutation profiling of CRCs diagnosed in African Americans (AAs), Ghanaians, Ethiopians, and NHWs, we explore correlations between population group and population-specific tumor variants. PATIENTS AND

methodsSomatic DNA from CRC tumors resected from 150 individuals, including 43 AAs (27%), 53 NHWs (35%), 21 Ghanaians (14.2%), and 33 Ethiopians (22.3%), was sequenced on the Illumina NovaSeq platform, targeting 290 genes. We compared mutations in AAs, Ghanaians, and Ethiopians to those in NHWs to identify variants enriched in historically underrepresented groups.

resultsUS cohort tumors were diagnosed at significantly younger ages with more early-onset cases (<50 years old) than African cohorts (

conclusionGeographic origin and age of onset appear to shape the CRC mutational landscape. The similarity between AA and NHW tumor profiles likely reflects their shared predominance of early-onset cases, suggesting that age- and geography-associated factors, including environmental exposures, may influence tumor phenotypes.

Indexed as

African ancestryColorectal cancergenetic ancestrymismatch repairpopulation-specific mutations

Identifiers

PMID42428056
PMCPMC13345582

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.